Freezing away phantom pain: new study tests two Nerve-Freezing techniques for amputees
NCT ID NCT07618689
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two ways to freeze painful nerve endings (neuromas) in people who lost limbs in combat. One method freezes the nerve right at the painful spot, the other freezes it further up the nerve. The goal is to see which provides better pain relief. Fifty adults with chronic neuroma pain will be enrolled, and their pain levels will be tracked over time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cryoablation (freezing nerve tissue)
- What this could lead to
- If it works, this could point toward a better way to manage stubborn nerve pain after amputation, improving mobility and quality of life.
- What could go wrong
- This is a small, early-stage study with only 50 participants, so results may not apply widely. Cryoablation may not provide lasting pain relief, and nerve damage could cause new symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years * Combat-related limb amputation * Chronic neuroma pain lasting ≥3 months * Ultrasound-confirmed painful neuroma * Average pain intensity ≥4/10 on Numeric Rating Scale * Positive Tinel sign * Ability to undergo ultrasound-guided cryoablation * Stable analgesic regimen for at least 14 days * Ability to provide written informed consent Exclusion Criteria: * Active infection at the treatment site * Open wound preventing safe procedure * Previous cryoablation of the target nerve within 6 months * Neuroma surgery within 3 months * Severe coagulopathy or anticoagulation contraindicating procedure * Pregnancy or breastfeeding * Severe uncontrolled systemic disease * Inability to complete follow-up assessments
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Vinnitsya university hospital
Vinnytsia, Вінницька, 21000, Ukraine
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Other studies related to the condition(s) this trial covers.
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