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Brain blood flow fix may reverse thinking decline

NCT ID NCT03121209

Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 19, 2026 · Updated 3 times

Summary

This study looks at people with severe but symptom-free narrowing of the carotid artery in the neck. It tests whether opening the artery with surgery or stenting can improve memory and thinking problems caused by poor blood flow to the brain. About 385 participants from a larger trial will have brain scans and thinking tests over one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
revascularization (carotid endarterectomy or stenting) plus intensive medical management
What this could lead to
If successful, this could show that treating narrowed carotid arteries improves thinking and memory in some patients, offering a new reason for the procedure beyond stroke prevention.
What could go wrong
This is an observational substudy, not a standalone trial. It may not prove cause and effect, and only a subset of patients with specific blood-flow problems might benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

392 people

The number who actually took part.

Started

Jan 2018

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 86 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Enrolled and randomized into CREST-2 (parent study) * Inclusion criteria for CREST-2 * age 35-86 Exclusion Criteria (in addition to the exclusion criteria for CREST-2): * unable to undergo MRI (e.g. metal in body, pacemaker) * known allergy gadolinium contrast dye * pre-existing diagnosis of dementia * contralateral ICA stenosis \>70% by MRA, CTA or Doppler ultrasound * history of severe head trauma * major depression * education less than 8 years

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Conditions

The condition(s) this trial relates to.

carotid stenosis Cognitive Dysfunction internal carotid artery stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive impairment Internal carotid artery stenosis

Contacts and locations

Locations

  • Adventist HealthCare/White Oak Medical Center

    Gaithersburg, Maryland, 20878, United States

  • Central Arkansas Veteran's Healthcare System

    Little Rock, Arkansas, 72143, United States

  • Gundersen Clinic, Ltd

    La Crosse, Wisconsin, 54601, United States

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Huntsville Hospital/ Heart Center Research Alabama

    Huntsville, Alabama, 35801, United States

  • Inova Fairfax Health Care

    Falls Church, Virginia, 22042, United States

  • Intermountain Medical Center

    Murray, Utah, 84107, United States

  • Kaiser Permanente

    San Diego, California, 92123, United States

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027, United States

  • Keck Medical Center of University of Southern California

    Los Angeles, California, 90033, United States

  • Louis Stokes Cleveland VA Medical Center

    Cleveland, Ohio, 44106, United States

  • Maine Medical Center

    Portland, Maine, 04102, United States

  • Mayo Clinic Florida

    Jacksonville, Florida, 322224, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Mercy Health Riverside

    Rockford, Illinois, 61114, United States

  • Mercy Hospital St Louis

    St Louis, Missouri, 63141, United States

  • Michigan Vascular Center/McLaren-Flint

    Flint, Michigan, 48532, United States

  • Minneapolis Clinic of Neurology, Ltd./ North Memorial Medical Center

    Golden Valley, Minnesota, 55422, United States

  • Morton Plant Hospital

    Clearwater, Florida, 33756, United States

  • New York Presbyterian Columbia University Medical Center

    New York, New York, 10032, United States

  • North Central Heart Institute

    Sioux Falls, South Dakota, 57108, United States

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Novant Health Forsythe

    Winston-Salem, North Carolina, 27103, United States

  • Ochsner Health System

    New Orleans, Louisiana, 70121, United States

  • Ohio Health Research Institute

    Columbus, Ohio, 43214,, United States

  • Ohio State Medical Center

    Columbus, Ohio, 43210, United States

  • Overlake Hospital Medical Center

    Bellevue, Washington, 98004, United States

  • SUNY Buffalo

    Buffalo, New York, 14203, United States

  • San Francisco VA Medical Center

    San Francisco, California, 94121, United States

  • St. Boniface Hospital

    Winnipeg, Manitoba, MB R2H 2A6, Canada

  • St. Joseph's Hospital and Medical Center/ Barrow

    Phoenix, Arizona, 85013, United States

  • Stanford University Medical Center

    Stanford, California, 94305, United States

  • Tennova Healthcare/ Turkey Creek Medical Center

    Knoxville, Tennessee, 37934, United States

  • The Miriam Hospital/ Rhode Island Hospital

    Providence, Rhode Island, 02906, United States

  • The University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • UPMC Altoona

    Altoona, Pennsylvania, 16601, United States

  • UPMC Presbyterian University Hospital

    Pittsburgh, Pennsylvania, 15213, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of California San Diego

    San Diego, California, 92182, United States

  • University of California at Los Angeles

    Los Angeles, California, 90095, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Florida Health at Shands

    Gainesville, Florida, 32610, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Maryland VA

    Baltimore, Maryland, 21201, United States

  • University of Miami Hospital

    Miami, Florida, 33136, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Utah Hospitals and Clinics

    Salt Lake City, Utah, 84132, United States

  • University of Virginia Health System

    Charlottesville, Virginia, 22908, United States

  • University of Washington Medicine-Harborview Medical Center

    Seattle, Washington, 98104, United States

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin, 53792, United States

  • VA Puget Sound Health Care System

    Seattle, Washington, 98108, United States

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Weill Cornell Medical Center

    New York, New York, 10065, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.