One-Dose wonder: could a single shot stop a deadly brain infection?

NCT ID NCT03945448

Recruiting now Disease control Sponsor: Makerere University Source: ClinicalTrials.gov ↗

First seen May 05, 2026 · Last updated May 24, 2026 · Updated 5 times

Summary

This study looks at whether giving a single, stronger dose of antifungal medicine (liposomal amphotericin) along with the standard drug (fluconazole) can prevent cryptococcal meningitis in people with HIV who test positive for the fungus but have no symptoms. About 356 adults in Uganda will take part. The goal is to see if the enhanced treatment reduces the number of people who develop meningitis over 24 weeks and improves survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

infectious Disease Institute Kampala,Uganda
RECRUITING

Kampala, Uganda

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

CRYPTOCOCCAL MENINGITIS