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Which knee implant feels more natural? a trial puts two designs to the test

NCT ID NCT07757581

Disease control Sponsor: Groupe Hospitalier Diaconesses Croix Saint-Simon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial compares two types of knee replacement implants: one that keeps the posterior cruciate ligament (CR) and one that does not (PS). Both are implanted using a computer-assisted personalized technique that aims to restore the knee's natural alignment. The study includes 140 adults with knee osteoarthritis who need a total knee replacement. The main goal is to see if patients report similar joint awareness and function 24 months after surgery, regardless of which implant they receive.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Knee replacement surgery using either a cruciate-retaining (CR) or posterior-stabilized (PS) prosthesis, implanted with a computer-assisted personalized technique.
What this could lead to
If successful, this could help surgeons choose the best implant design for personalized knee replacement, potentially improving patient satisfaction and joint function.
What could go wrong
This is a single-center trial, and results may not apply to all patients or surgical settings. The study is not designed to prove one implant is superior, only to check if they are similar.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

140 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient information provided and signed written informed consent obtained in duplicate * Male and female participants aged 18 years or older * Primary total knee arthroplasty for knee osteoarthritis performed in the orthopaedic surgery department Exclusion Criteria: * History of posterior cruciate ligament (PCL) rupture or prior ligamentoplasty * History of ipsilateral femur or tibia fracture * Coronal plane axial deviation greater than 15 degrees (HKA \< 165° or \> 195°) * Flexion contracture (flexum) greater than 15 degrees * Tibial slope greater than 10 degrees * Patient deprived of liberty by judicial or administrative decision * Patient not affiliated with or beneficiary of a national social security scheme * Patient unable to understand French * Patient whose place of residence is incompatible with close in-person follow-up consultations * Woman of childbearing potential not using effective contraception * Pregnant or breastfeeding woman * Adult patient unable or unfit to give informed consent

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthroplasty Osteoarthritis, knee

Contacts and locations

Locations

  • Groupe hospitalier Diaconesses Croix Saint Simon

    Paris, 75020, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.