Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New study tracks COVID-19 vaccine response in young cancer patients

NCT ID NCT05228275

Knowledge-focused Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study follows 549 children, teens, and young adults with cancer to see how their immune systems respond to COVID-19 vaccines. Researchers collect blood samples to measure protective antibodies. The goal is to learn how cancer and its treatment affect vaccine effectiveness, and whether timing or extra doses help.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors understand how to best time COVID-19 vaccines for young cancer patients to maximize protection.
What could go wrong
This is an observational study, not a treatment trial. It only measures immune responses and does not test whether the vaccine prevents infection. Results may vary by cancer type and treatment stage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 549 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2022

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children and young adults with cancer receiving approved COVID-19 vaccines

Ages

6 months to 37 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>= 6 months and =\< 37 years of age at time of enrollment * Patient plans to receive their first COVID-19 vaccine dose one of the food and drug administration (FDA) approved/FDA-emergency use authorization (EUA) approved COVID-19 vaccines OR patient already received their first COVID-19 vaccine dose =\< 24 months prior to enrollment using one of the FDA approved/FDA-EUA approved COVID-19 vaccines. * Note: for this observational study, the decision to vaccinate is according to local discretion and should be made prior to consideration of enrollment * Must have a diagnosis of cancer * Patient must be undergoing or have previously received one of the following cancer treatments within 12 months before their first COVID-19 vaccine dose: * Dosing with chemotherapy or immunotherapy agent, including tyrosine kinase inhibitors and small molecule inhibitors targeting cancer * Dosing with monoclonal antibodies targeting B-cell antigens (e.g., Rituximab), or Bruton tyrosine kinase inhibitors or Janus Kinase inhibitors * Stem cell infusion for bone marrow transplant or CAR-T infusion for cellular therapy * A patient enrolling prior to their first COVID-19 vaccine dose is eligible only if it is feasible to collect required baseline study specimens within protocol mandated time period prior to the initial COVID-19 vaccine dose; or a patient who already received a COVID-19 vaccine is eligible only if feasible to collect at least one post-first-dose follow-up specimen (i.e., at minimum, collection of the 24m PFD follow-up specimen must be feasible as per timing requirements * Note: for this observational study, the vaccine timing and regimen will proceed according to local discretion. Patients enrolled prior to their first COVID-19 vaccine dose who do not receive initial vaccine dose within 3 months after enrollment will be taken off study * All patients and/or their parents or legal guardians must sign a written informed consent * All institutional, FDA, and National Cancer Institute (NCI) requirements for human studies must be met Exclusion Criteria: * Documented SARS-CoV-2 monoclonal antibody infusion or convalescent plasma after COVID-19 infection within last 90 days * Note: patients with previous COVID-19 infection are eligible as long as requirements are met. Patients receiving intravenous immunoglobulin therapy (IVIG) therapy (i.e., post bone marrow transplantation \[BMT\] or chimeric antigen receptor \[CAR\]-T) are eligible * Patients undergoing radiation therapy only are ineligible * Reminder: before the planned initial COVID-19 vaccine dose, patient must be undergoing or have received cancer treatments

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COVID-19 infection are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

cancer COVID-19 hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 infection Hematopoietic and lymphatic system neoplasm Malignant solid neoplasm

Contacts and locations

Locations

  • Albany Medical Center

    Albany, New York, 12208, United States

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada, 89135, United States

  • Bronson Methodist Hospital

    Kalamazoo, Michigan, 49007, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri, 63104, United States

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska, 68114, United States

  • Children's Hospital at Montefiore

    The Bronx, New York, 10467, United States

  • Children's Hospital of Alabama

    Birmingham, Alabama, 35233, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Comprehensive Cancer Centers of Nevada - Town Center

    Las Vegas, Nevada, 89144, United States

  • Corewell Health Children's

    Royal Oak, Michigan, 48073, United States

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan, 49503, United States

  • Dayton Children's Hospital

    Dayton, Ohio, 45404, United States

  • Dell Children's Medical Center of Central Texas

    Austin, Texas, 78723, United States

  • Drexel University School of Medicine

    Philadelphia, Pennsylvania, 19102, United States

  • Driscoll Children's Hospital

    Corpus Christi, Texas, 78411, United States

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee, 37916, United States

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida, 33908, United States

  • Hope Cancer Care of Nevada-Pahrump

    Pahrump, Nevada, 89048, United States

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Kingman Regional Medical Center

    Kingman, Arizona, 86401, United States

  • Las Vegas Urology - Cathedral Rock

    Las Vegas, Nevada, 89128, United States

  • Las Vegas Urology - Pebble

    Henderson, Nevada, 89074, United States

  • Las Vegas Urology - Pecos

    Las Vegas, Nevada, 89074, United States

  • Las Vegas Urology - Smoke Ranch

    Las Vegas, Nevada, 89128, United States

  • Madigan Army Medical Center

    Tacoma, Washington, 98431, United States

  • Maine Children's Cancer Program

    Scarborough, Maine, 04074, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida, 33021, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas, 78229, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York, 10461, United States

  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York, 10461, United States

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida, 32207, United States

  • Nemours Children's Hospital

    Orlando, Florida, 32827, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

  • OSF Children's Hospital of Illinois

    Peoria, Illinois, 61637, United States

  • Oncology Las Vegas - Henderson

    Henderson, Nevada, 89074, United States

  • Overlake Medical Center

    Bellevue, Washington, 98004, United States

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington, 99204, United States

  • Radiation Oncology Associates

    Reno, Nevada, 89509, United States

  • Rady Children's Hospital - San Diego

    San Diego, California, 92123, United States

  • Renown Regional Medical Center

    Reno, Nevada, 89502, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Sacred Heart Hospital

    Pensacola, Florida, 32504, United States

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania, 19134, United States

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida, 33607, United States

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey, 07503, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    Sturgeon Bay, Wisconsin, 54235-1495, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Sinai Hospital of Baltimore

    Baltimore, Maryland, 21215, United States

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada, 89144, United States

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada, 89109, United States

  • Tampa General Hospital

    Tampa, Florida, 33606, United States

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee, 37203, United States

  • UCSF Benioff Children's Hospital Oakland

    Oakland, California, 94609, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada, 89102, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.