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Cortisol clues: why some patients get low blood sugar after Weight-Loss surgery

NCT ID NCT06896682

Knowledge-focused Sponsor: Esbjerg Hospital - University Hospital of Southern Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study looks at how bariatric surgery changes cortisol metabolism and whether that contributes to reactive hypoglycemia (low blood sugar after meals). Researchers will measure cortisol levels during a meal test and check adrenal function in 100 people who had gastric bypass or sleeve surgery at least a year ago. The goal is to understand the link between cortisol and post-surgery blood sugar dips.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could clarify why some people develop low blood sugar after bariatric surgery, potentially pointing toward better prevention or management strategies.
What could go wrong
This is an observational study, not a treatment trial. It aims to understand a mechanism, not test a therapy, so direct patient benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

postbariatric patients

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants must have undergone one of the following bariatric procedures at least 12 months prior: * Roux-en-Y gastric bypass * Gastric sleeve Exclusion Criteria * Pregnancy and breastfeeding * Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration * Use of corticosteroid medications, such as prednisolone * Use of opiod-containing medication * Use of medications containing estrogen, such as hormone therapy for menopause * Known adrenal disease affecting cortisol metabolism, including autonomous cortisol production and Cushing's syndrome * Diabetes that does not require medical treatment * Previously diagnosed reactive hypoglycemia after bariatric surgery requiring medical treatment

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Conditions

The condition(s) this trial relates to.

dumping syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postbariatric hypoglycemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Esbjerg Hospital

    RECRUITING

    Esbjerg, 6700, Denmark

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