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Zapping the brain to improve walking after stroke: a new study explores the possibility

NCT ID NCT06681207

Knowledge-focused Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether a gentle brain stimulation technique called anodal tDCS can improve how people learn stepping movements. Researchers will test this in both healthy adults and chronic stroke survivors. Participants will receive either real stimulation, a sham (fake) stimulation, or no stimulation while practicing stepping onto visual targets over five days. The goal is to understand how brain stimulation affects leg skill learning and brain activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
anodal transcranial direct current stimulation (a-tDCS)
What this could lead to
If successful, this could point toward a way to improve walking rehabilitation after stroke by combining brain stimulation with stepping practice.
What could go wrong
This is an early exploratory study with only 108 participants, so results may not apply widely. The brain stimulation is mild and temporary, and the main goal is to learn about brain activity, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 21 and 90 years 2. Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment 3. MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract 4. Hemiparesis involving the lower extremity (Fulg-Meyer LE motor test) 5. No passive range of motion limitation in bilateral hips and knees 6. Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less 7. Visual acuity can be corrected by glasses or contact lens to 20/20 8. Able to walk independently with/without assistant devices for 10 meters 9. Able to maintain standing position without any assistance \> 30 sec (Short Physical Performance Battery) 10. Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24 Exclusion Criteria: 1. Pregnant women 2. MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or malignant neoplasm or tumors 3. Have any metal implants, cardiac pacemakers, or history of seizures 4. Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training 5. Any vestibular dysfunction or unstable angina 6. Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia\*

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Physical Therapy, University of Texas Medical Branch

    RECRUITING

    Galveston, Texas, 77555, United States

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