Mushroom supplement may enhance workout endurance and mood
NCT ID NCT07310108
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a daily cordyceps mushroom supplement helps healthy, active adults exercise longer, improve heart fitness, and feel better during recovery. Thirty-two adults aged 20 to 50 who exercise regularly took either the supplement or a placebo for several weeks. Researchers measured cycling endurance, oxygen use, mood, and stress markers to see if the fungus made a difference.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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32 people
The number who actually took part.
- Started
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May 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Healthy males and females aged 20 to 50 years of age. Individual indicates they are currently engaged in and historically engaged in exercise (i.e., structured or unstructured) for the prior 12 months. Subject has the ability to exercise on a cycle ergometer without issue or concern. Subject has the ability to "sprint" (cycle Time to Exhaustion Trial) without any orthopedic or other limitations. Body Mass Index (BMI) 19 to 29.9 kg/m2 (normal weight to overweight status) Subject is in good health and appropriate for exercise as determined by physical examination, medical history and the Physical Activity Readiness Questionnaire (PAR-Q). Subject can exercise on a cycle ergometer without issue or concern. Subject is a non-smoker. Subject agrees to not use any new vitamin, mineral, or dietary supplement product until after study completion and to not take any vitamins, minerals or dietary supplements 24 hours prior to the exercise test visits. Subject is willing and able to comply with the protocol including: attending the study scheduled appointments, of which two of the study visits may take up to five hours for completion. Subject agrees to refrain from exercise for the 24 hours prior to any test visits. Subject agrees to refrain from alcohol use for at least 24 hours before every study visit. Subject agrees to refrain from using any antihistamines for the 24 hours prior to the exercise test visits. Subject agrees to refrain from drinking any exercise recovery beverages during the study period. Subject is able to understand and sign the informed consent to participate in the study. Exclusion Criteria: Subject has any of the following medical conditions: active heart disease, uncontrolled high blood pressure (≥ 140/90 mmHg), renal or hepatic impairment/disease, Type I or II diabetes, bipolar disorder, Parkinson's disease, unstable thyroid disease, immune disorder (such as HIV/AIDS), any medical condition deemed exclusionary by the Principal Investigator (PI) Subject has a history of cancer (except localized skin cancer without metastases) within 5 years prior to screening. Subject has a medical condition or orthopedic problem making exercising on a cycle ergometer contraindicated. Subject has a VO2 peak/max value above the following age/sex categorizations (as measured during Visit 1): Males 20-29y - 47.5 mL/kg/min, Males 30-39y - 46.0 mL/kg/min, Males 40-45y - 43.9 mL/kg/min, Females 20-29y - 41.0 mL/kg/min, Females 30-39y - 39.6 mL/kg/min, Females 40-45y - 38.1 mL/kg/min Subject is currently taking antihypertensives, hypoglycemic medications or stimulatory asthma medications. Subject is on an unstable dose of medication (defined as fewer than 90 days at the same dose). Subject is taking a prescription medication deemed exclusionary by the Principal Investigator (PI). Subject has an allergy to any ingredients in the Study Product. Subject has a history of drug or alcohol abuse in the past 12 months. Subject has a history of a psychiatric illness requiring hospitalization in the past 12 months. Subject has any condition or abnormality that in the expert opinion of the PI, participation in the study would compromise the safety of the subject or the quality of the study data. Subject is participating in or has participated in another research study within 30 days prior to the Screening visit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Lindenwood University Exercise and Performance Nutrition Laboratory
Saint Charles, Missouri, 63301, United States
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Other studies related to the condition(s) this trial covers.
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