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COPD mystery: could low lung blood volume explain breathlessness?

NCT ID NCT07428785

Knowledge-focused Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares 16 people with mild-to-moderate COPD to 16 healthy volunteers matched by age, sex, and height. Researchers measure blood volume in the lungs and the whole body to see if a smaller lung blood volume contributes to exercise problems. No treatment is given—the goal is simply to better understand the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study succeeds, it could reveal a new reason why people with COPD struggle with exercise and shortness of breath, pointing toward future treatments.
What could go wrong
This is a small, early observational study with only 32 participants. It measures blood volumes, not treatments, so it may not lead directly to any new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Sjælland, Denmark

Ages

45 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inclusion criteria -patients * Men and women * 45-80 years * COPD (GOLD stage I to III) * Resting arterial oxygenation \> 90% Inclusion criteria - controls * Men and women * 45-80 years * Normal FEV1, FVC, FEV1/FVC, and single-breath diffusion capacity * Same sex, age (± 3 years) and height (± 5 cm) as an included COPD patient * Low- to moderate activity level defined as \< 1,5 hours of structured physical activity pr. week at moderate intensity and cycling \< 30 minutes/5km pr. day at moderate intensity (moderate intensity = out of breath but able to speak) Exclusion Criteria: Exclusion criteria - patients * Symptoms of ischaemic heart disease * Known heart failure * Previous severe or current COVID-19 * Claudication * Symptoms of disease within 2 weeks prior to the study * Participation in pulmonary rehabilitation within 6 months * Known malignant disease * Pregnancy * Unstable cardiac arrhythmic disease * Renal or liver dysfunction Exclusion criteria - controls * Known chronic lung disease * Known ischaemic heart disease * Known heart failure * Previous severe or current COVID-19 * Symptoms of disease within 2 weeks prior to the study * Known malignant disease * Claudication * Pregnancy * Unstable cardiac arrhythmic disease * Renal or liver dysfunction

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD (chronic obstructive pulmonary disease) Healthy subjects

Contacts and locations

Locations

  • Center for Aktiv Sundhed

    Copenhagen, 2100, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.