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Should ICU patients eat before tube removal? new study challenges old practice

NCT ID NCT06382727

Knowledge-focused Sponsor: Emma Ridley Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study looked at whether continuing liquid feeding (enteral nutrition) right up to the moment a breathing tube is removed is better than the usual practice of fasting for at least 4 hours. The study involved 60 critically ill adults in the ICU who were on a ventilator. The goal was to see if this approach reduces the total hours of fasting before tube removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
enteral nutrition (liquid feeding via tube)
What this could lead to
If it works, this could change ICU routines to reduce unnecessary fasting before breathing tube removal.
What could go wrong
This is a small pilot study (60 patients) and may not prove safety or benefit. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

May 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older * Receiving invasive mechanical ventilation \> 24 hours and \< 10 days in the index ICU admission * Receiving EN at a rate ≥ 30ml/hr * Planned for extubation within the hours of 0800-1800 Exclusion Criteria: * EN delivery via a fine bore nasogastric tube that is unable to be aspirated * A single gastric residual volume ≥ the maximum protocol limit at the participating site has been recorded within the last 24 hours * Currently receiving extracorporeal membrane oxygenation * Acute neurological pathology * A time critical medication is required via the enteral route (including anti-parkinsons and immunosuppressant medication) and no adjustments can be made * Pre-existing swallow, bulbar dysfunction and/or concern around inadequate airway protection * A laparotomy has been performed within 72 hours of planned extubation * Confirmed pregnancy * Patient not deemed appropriate to be reintubated in the event of deterioration * Treating clinician believes enrolment is not in the best interests of the patient

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Conditions

The condition(s) this trial relates to.

Critical Illness Fasting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness

Contacts and locations

Locations

  • Gold Coast University Hospital

    Southport, Queensland, 4215, Australia

  • St Vincent's Hospital Melbourne

    Fitzroy, Victoria, 3065, Australia

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

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