New lung camera could spot cancer in real time

NCT ID NCT01931579

Diagnosis Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a special microscope on a thin probe (confocal endo-microscopy) that doctors can use during a bronchoscopy to look at lung nodules up close. The goal was to see if it can help tell whether a nodule is cancer or not, right then and there. 120 adults with a lung nodule took part. The probe was inserted through the same tube used for standard navigational bronchoscopy, and images were recorded before taking a tissue sample.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: confocal endo-microscopy device (CELLVIZIO)
What this could lead to: If successful, this could give doctors a real-time way to see whether a lung nodule is cancerous during a bronchoscopy, potentially reducing the need for additional procedures.
What could go wrong: This is a completed early-stage study with 120 participants, so results may not apply to all patients. The technology may not always clearly distinguish benign from malignant nodules.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Start date

May 2012

Finished

Jun 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with a peripheral lung nodule accessible by navigational bronchoscopy and CELLVIZIO according to Investigator evaluation of the CT scan. * 18 years old or more. * Affiliation to french social security insurance. * Signed informed consent for the procedure. Exclusion Criteria: * Severe respiratory insufficiency that will not allow the bronchoscopy procedure * Uncorrected bleeding disorders * History of pneumonectomy or exploration controlateral to a non functional lung, * Pregnant or breast feeding woman, or person not authorized to participate to a clinical trial according to L1121-6 et L1121-8 of French Code of Public Health, concurrent participation to another clinical trial

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Conditions

The condition(s) this trial relates to.

respiratory system benign neoplasm respiratory system cancer respiratory tract neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Benign neoplasms of the respiratory system Malignant neoplasm of the respiratory system Pulmonary nodule persistent

Contacts and locations

Locations

CHU Saint Etienne

Saint-Etienne, 42055, France
CHU Toulouse

Toulouse, 31059, France
UHRouen

Rouen, 76031, France