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Talking therapy could ease menopause mood swings without hormones

NCT ID NCT06462157

Symptom relief Sponsor: University College, London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a 6-session online group program called Compassionate Mind Training (CMT) can improve wellbeing in women aged 40-60 going through menopause. The therapy aims to reduce self-criticism and shame by building self-compassion. Researchers enrolled 38 women to see if the approach is practical and acceptable, and to measure changes in mood, anxiety, and quality of life. This is a very early feasibility study, not a large-scale effectiveness trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Compassionate Mind Training (CMT) - a psychological therapy delivered in online group sessions
What this could lead to
If it works, this could offer a non-hormonal, drug-free option to help women manage menopause-related emotional difficulties like low mood and self-criticism.
What could go wrong
This is a very small, early feasibility study with only 38 participants and no control group for efficacy. Results may not apply to all women, and the therapy may not produce lasting benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Jun 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 60 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (aged 40-60) who are biologically female * Women who are experiencing symptoms of the menopause or peri-menopause; which is naturally occurring. This is identified through the STRAW criteria. Individuals have to answer Yes on at least one of the STRAW screening questions to ensure women are in the perimenopause or menopausal period. * Substantial English verbal communication and comprehension skills * Capacity to consent * Confident in using video conferencing applications (MsTeams) * Willingness to take part in a post-intervention interview about their experience. * PHQ-9 score 5-19 (mild to moderate clinical cut offs) * GAD-7 score 5-15 (mild to moderate clinical cut offs) Exclusion Criteria: * People under the age of 40 * People currently receiving any form of psychology intervention. * Transgender females who are biologically male * More than 5 years post menopause. * PHQ-9 score greater or equal to 20 (severe clinical cut off) * GAD-7 score greater or equal to 15 (severe clinical cut off)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menopause

Contacts and locations

Locations

  • University College London

    London, County, WC1E 6BT, United Kingdom

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