New study pits two wrinkle fillers Head-to-Head for smile lines
NCT ID NCT06351293
First seen Jan 19, 2026 · Last updated May 19, 2026 · Updated 19 times
Summary
This study tested two hyaluronic acid fillers, Defyne and RHA3, to see which works better for smile lines (nasolabial folds). Fifteen adults received one filler on each side of their face, with optional touch-ups after 4 weeks. Researchers used ultrasound and 3D imaging to compare results over 12 months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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The Aesthetic Clinique
Santa Rosa Beach, Florida, 32459, United States
Conditions
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