Which numbing drug works best for leg surgery?
NCT ID NCT01935596
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compared two numbing medicines, levobupivacaine and ropivacaine, given as spinal anesthesia for leg surgery. Fifty adults with leg injuries took part. Researchers measured how long numbness and muscle relaxation lasted. The goal was to see if one drug works better or lasts longer than the other.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- levobupivacaine and ropivacaine (local anesthetics)
- What this could lead to
- If one anesthetic works better, it could help doctors choose the best option for numbing during leg surgery, improving patient comfort and recovery.
- What could go wrong
- This is a small, completed study with only 50 people, so results may not apply to everyone. Both drugs are already approved, so no major breakthrough is expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
50 people
The number who actually took part.
- Start date
-
May 2013
- Finished
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Apr 2014
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * patient admitted to the emergency for lower limb trauma, * age over 18 years and below 65 years * lower limb trauma surgery can be performed under spinal anesthesia. Exclusion Criteria: * Refusal of patients to participate in the study, * Patient with cons-indication to spinal anesthesia: * Local anesthetic allergy agents (1/13000) * bleeding disorders, including pharmacological origin * infection at the puncture site, * refusal of spinal anesthesia by the patient, * Patient trust, * Patients whose coagulation is abnormal. * Patients with cognitive impairment or incapacitated adult, * Multiple trauma, * Porphyria, * Central preexisting neuropathy, * A history of spinal surgery, * Epilepsy uncontrolled by treatment, * Hypovolemia, * Pregnant or lactating women, * Participation in another ongoing clinical trial, * Patient on anticoagulant therapy, * Patient not affiliated with a social security system.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hervé DUPONT
Amiens, Picardie, 80054, France