Eye drop showdown: three Anti-Inflammatories battle to save sight after cataract surgery
NCT ID NCT07178639
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This study compares three different NSAID eye drops (bromfenac, nepafenac, and diclofenac) to see which one best prevents cystoid macular edema, a type of swelling that can blur vision after cataract surgery. About 150 adults having cataract surgery will be randomly assigned to one of the three drops. They will be followed for six weeks with eye exams and vision tests. The goal is to find the most effective option for routine use.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- NSAID eye drops (bromfenac, nepafenac, diclofenac)
- What this could lead to
- If successful, this could identify which eye drop works best to prevent vision-threatening swelling after cataract surgery, improving recovery for millions.
- What could go wrong
- This is a small, early-stage comparison trial (150 people) with no placebo group. Results may not apply to all patients, and differences between drugs may be small.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Feb 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Are male or female at least 18 years of age who require cataract surgery and no other surgical procedures during the cataract surgery. * Agree not to have any other ocular surgical procedures in the study or fellow (non study) eye within 15 days prior to the initiation of dosing with the test article or throughout the duration of the study. * Have a Best Corrected Visual Acuity of 20/200 or better in either eye. * Are able to self administer test article (or have a caregiver available to instill all doses of test article). Exclusion Criteria: * Have known hypersensitivity to bromfenac, nepafenac, diclofenac or any component of the test article (including "procedural" medications such as anesthetic and/or fluorescein drops, dilating drops, etc.). * Have intraocular inflammation (i.e., cells or flare in the anterior chamber as measured on slit lamp examination) in study eye at screening visit. * Have a known blood dyscrasia or bone marrow suppression, a diagnosis of uncontrolled/unstable peptic ulcer disease, inflammatory bowel disease, or ulcerative colitis, or any uncontrolled/unstable pulmonary, cardiac, vascular, autoimmune, hepatic, renal, or central nervous system disease. * Have used ocular, topical, or systemic NSAIDs or ocular, topical, or systemic gentamicin, or cyclosporine ophthalmic emulsion within 7 days prior to initiation of dosing with the test article or throughout the duration of study,with exception of allowing patients on a stable dose of aspirin 81 mg daily or less. * Have diabetes of any type. * Have any pathology of vitreoretinal interface (recognised on opcital coherence tomography). * Have any history of pars plana vitrectomy in the study eye. * Have glaucoma of the following types: any secondary, closed angle, severe open angle. * Have used ocular prostaglandins within 30 days prior to initiation of dosing with test article or throughout the duration of study. * Have active corneal pathology noted in the study eye at screening visit. Active corneal pathology is defined as corneal pathology that is non stable, or greater than mild, or will compromise assessment of the safety or efficacy of treatment. Superficial punctate keratitis in study eye. * Have any extraocular/intraocular inflammation in the study eye at screening visit (blepharitis allowed if mild only, and no concurrent conjunctivitis or lid erythema/edema) or ongoing, unresolved uveitis. * Have used topical, ocular, inhaled or systemic steroids within 14 days prior to screening. * Have a history of abuse of alcohol/drugs within six months prior to the screening visit. * Are pregnant or nursing/lactating. * Have participated in any other study of an investigational drug or device within 30 days prior to randomization.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Oblastní nemocnice Kolín a.s.
RECRUITINGKolín, 28002, Czechia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- One operation for cataract and glaucoma? eye surgeons test a Two-in-One approach
- Tiny corneal pockets tested as Suture-Free seal for cataract incisions
- Eye drops may shield the cornea after cataract surgery
- Can cataract surgery reduce fear of falling in older adults?