New study aims to make dental extractions Pain-Free by testing better anesthetics
NCT ID NCT07597408
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two local anesthetics (articaine and buffered lidocaine) for extracting upper teeth. The goal is to see if one can numb the tooth effectively without needing a separate, painful injection into the palate. Fifty healthy adults needing extraction of a matching pair of upper teeth will receive each anesthetic in separate sessions, and researchers will measure pain, numbness onset, and duration.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- articaine hydrochloride and buffered lidocaine hydrochloride
- What this could lead to
- If one anesthetic works better, it could make dental extractions less painful and reduce patient fear by avoiding a separate injection into the palate.
- What could go wrong
- This is a small, early study (50 people) comparing two well-known drugs, so the results may not apply to everyone or change practice dramatically.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Jul 2025
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Inclusion Criteria: 1. Systemically healthy patients 2. Patiens age between 18-60 years 3. Patients with no allergy to amide local anesthetics 4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria <!-- --> 1. Patients younger than 18 years 2. Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment) 3. Patients with sickle cell anemia 4. Patiens allergic to amid local anesthetics Exclusion Criteria:
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Latakia university
Latakia, Syria