New anesthesia approach may speed recovery in lung cancer surgery
NCT ID NCT07327736
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two types of anesthesia for early-stage lung cancer surgery: one that lets patients breathe on their own and one that uses a breathing tube. Researchers want to see which method leads to a shorter hospital stay and less pain medication use. The study will include 410 adults with small lung tumors (3 cm or less) and aims to find a safer, more effective way to perform surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 410 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2032
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Up to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≤ 75 years; * Gender is not limited; * Patients with suspected T1 stage non-small cell lung cancer (NSCLC) in preoperative clinical staging, with thin-slice CT showing that the maximum tumor diameter is ≤ 3.0 cm, single or multiple nodules, and the nodules requiring surgical resection are located in the same ipsilateral lung lobe, with the number of nodules resected simultaneously ≤ 3; * American Society of Anesthesiologists (ASA) classification ≤ Grade III (preferably Grade I - II is recommended); * Eastern Cooperative Oncology Group (ECOG) performance status 0 - 1; * Body Mass Index (BMI) \< 25 kg·m-²; * Normal cardiopulmonary function: predicted forced expiratory volume in the first second (FEV1%) \> 50%, resting blood gas analysis showing arterial oxygen partial pressure (PaO2) ≥ 75 mmHg, arterial carbon dioxide partial pressure (PaCO2) \< 45 mmHg; ejection fraction (EF) \> 50%, 6-minute walk distance (6MWD) ≥ 350 m; * No severe upper airway lesions, Mallampati classification I - II; * No contraindications related to paravertebral nerve block and intercostal nerve block; * Estimated surgical time ≤ 150 minutes; * Patients have no history of clinically significant cardiac or neurological problems. Exclusion Criteria: * A history of ipsilateral lung surgery; * Interstitial pneumonia, pulmonary fibrosis, severe emphysema, severe chronic obstructive pulmonary disease, acute phase of pulmonary infection, or uncontrolled asthma; * Sleep apnea syndrome with anticipated airway difficulty or difficulty in airway management; * Preoperative complications including coagulation dysfunction, hypoxemia, hypercapnia, or hepatic/renal insufficiency; * Alteration of anesthesia or surgical plan; * Persistent cough or increased risk of high airway secretion reflux; * Mental disorders, inability to communicate, or refusal to sign the informed consent form; * Participation in other clinical trials within 1 month before this trial; * Those who are deemed unfit to participate in this trial by the researchers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
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A doctor treating you
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