Heart ablation showdown: simpler method may be just as good

NCT ID NCT07118046

Disease control Sponsor: Daniel Rodríguez Muñoz Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares two ways to perform a heart ablation for atrial fibrillation: one using only X-ray guidance, and the other adding a 3D mapping system. Researchers want to see if the simpler X-ray-only method is just as effective at isolating the pulmonary veins, which is key to controlling the irregular heartbeat. The trial will enroll 96 adults with paroxysmal or persistent atrial fibrillation who need this procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: pulsed-field ablation via balloon catheter
What this could lead to: If successful, this could show that a simpler, fluoroscopy-only approach is just as effective as using additional mapping technology for treating atrial fibrillation.
What could go wrong: This is a small, early-stage study (96 participants) comparing two techniques, not testing a new drug. It may not show a clear difference, and results may not apply to all patients with atrial fibrillation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 96 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years old * Diagnosed with paroxysmal or persistent AF * Clinical indication to undergo PVI Exclusion Criteria: * Prior PVI or left atrial linear ablation * Severe frailty or life expectancy \<1 year * Unwillingness or inability to provide informed consent * Ablation at sites beyond PVI or indication for additional electrophysiological study * Contraindication or intolerance to heparin * Presence of left atrial thrombus * Congenital heart disease * Pregnancy, ongoing or planned in the following 6 months

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Conditions

The condition(s) this trial relates to.

atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Heart ablation showdown: simpler method may be just as good

What the study statuses mean