Brain pacemaker targets seizures in Drug-Resistant epilepsy
NCT ID NCT07458217
First seen Jun 25, 2026 · Last updated Sep 02, 2026 · Updated 7 times
Summary
This pilot study tests a deep brain stimulation device that sends electrical pulses to two brain areas (STN and CM) to reduce seizures in adults with drug-resistant motor epilepsy. Ten participants will have the device implanted and will be monitored for changes in seizure frequency and any side effects. The goal is to see if this combined stimulation is safe and effective for people whose seizures don't respond to medication.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- deep brain stimulation device
- What this could lead to
- If successful, this could offer a new way to reduce seizures in people with motor epilepsy that doesn't respond to medication.
- What could go wrong
- This is a very small, early pilot study with only 10 participants, so results may not apply widely. Deep brain stimulation also carries risks like infection or side effects from the implant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\) 18-65 Years. * 2\) Drug Resistant Epilepsy. * 3\) Motor Epilepsy - defined as: 1. Epilepsy diagnosis meeting ILAE criteria 2. Motor Epilepsy defined as including one or more of: i. Tonic, Clonic, or Tonic-Clonic activity; ii. Myoclonic Jerks; iii.Epileptic Spasms; iv.Focal Motor Seizures (identified primary lesion will be in motor functional area, such as primary motor cortex (BA4), pre-motor cortex (BA6), Central Posterior Gyrus (BA1-3), or other motor region); v.Motor activity not secondary to non-motor seizure. c.Clinical or Electrographic corroboration of at least one of: i.Video-EEG confirmation of motor seizure semiology; ii.Interictal or ictal EEG findings consistent with epileptic motor network involvement; iii.Consistent clinical description by trained cliniciants. * 4\) \>3 Focal or Generalized seizures / month with an inter-seizure interval no great than 30 days. * 5\) Subject or caregiver is able to provide epileptic seizure record within 90 days prior to the surgery. * 6\) Voluntarily participate in the trial, sign the informed consent form, and be willing to comply with study requirements, including follow-ups. Exclusion Criteria: * 1\) Non Motor Epilepsy. * 2\) Previous diagnosis of psychogenic/non-epileptic seizures. * 3\) Brain lesion resection or ablation surgery performed less than 6 months. * 4\) Implanted Vagus nerve stimulation (VNS) or responsive neurostimulation (RNS) devices recommended neither stimulation off the device at least 6 months nor remove the device. * 5\) Pregnant, breastfeeding, or having the intention to become pregnant during the study period (for females of childbearing potential).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.