New combo therapy aims to heal Radiation-Damaged jaw bones
NCT ID NCT06055257
First seen Oct 31, 2025 · Last updated Jun 23, 2026 · Updated 32 times
Summary
Radiation for head and neck cancer can sometimes cause a painful condition where the jaw bone dies (osteoradionecrosis). This pilot study tests whether adding a special drug cocktail (mPENTOCLO) to standard hyperbaric oxygen therapy works better than oxygen alone. The study will enroll 24 people and focus on whether the treatment plan is practical and if it reduces pain and the need for surgery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sunnybrook Health Sciences Centre
RECRUITINGToronto, Ontario, M4N3M5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mPENTOCLO (pentoxifylline, tocopherol, and clodronate) plus hyperbaric oxygen therapy
What this could lead to
If successful, this combination could offer a more effective, non-surgical treatment for radiation-induced jaw bone damage, reducing pain and the need for surgery.
What could go wrong
This is a very small pilot study (24 people) focused on feasibility, not proof of effectiveness. The drug regimen is complex and long (12 months), and hyperbaric oxygen requires many clinic visits.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.