New drug may help gut wake up faster after colon surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * American Society of Anesthesiologists (ASA) physical status classification I-III * Preoperative Mini-Mental State Examination (MMSE) score \> 23 * Patients scheduled for elective colorectal surgery under general anesthesia. Disease diagnoses include colorectal cancer, benign polyps, benign strictures, or diverticular disease. * Provide informed consent Exclusion Criteria: * Presence of psychiatric disorders, cognitive impairment, or language communication barriers that may affect assessment compliance. * Body Mass Index (BMI) ≥ 35 kg/m². * Severe hepatic dysfunction (Child-Pugh Class C) or renal dysfunction (estimated glomerular filtration rate \< 30 ml/min/1.73m² and/or receiving renal replacement therapy). * Pre-existing severe gastrointestinal dysfunction (e.g., intestinal obstruction, active inflammatory bowel disease, severe constipation/diarrhea); receipt of neoadjuvant therapy preoperatively; planned stoma creation surgery; or scheduled for low rectal surgery (e.g., low anterior resection, abdominoperineal resection). * History of neuromuscular disorders (e.g., myasthenia gravis) or malignant hyperthermia. * History of opioid abuse, or chronic non-surgical pain requiring long-term analgesic therapy. * Anticipated difficult airway, or patients planned for postoperative transfer to the intensive care unit (ICU) while intubated. * Contraindications to the use of neostigmine, atropine, sugammadex, or rocuronium (e.g., known drug allergy, epilepsy, unstable angina, asthma, glaucoma, uncontrolled malignant arrhythmias especially atrioventricular block, severe cardiac valve stenosis); or current use of medications that may significantly influence the effects of neuromuscular blocking agents (e.g., antibiotics such as tetracyclines, aminoglycosides, polymyxins, and clindamycin; antiepileptic drugs; lithium; certain antidepressants such as sertraline and amitriptyline). * Pregnant or lactating women. * Current participation in other clinical trials that may interfere with the results of this study.