50,000 cancer patients join landmark study to unlock better treatments
NCT ID NCT02070146
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows 50,000 people with colorectal, small bowel, or anal cancer to learn why some respond better to treatment than others. Researchers will collect data on genetics, lifestyle, and side effects to improve care for all patients, not just those in clinical trials. Participants can also join other studies at the same time.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better predict outcomes and tailor treatments for colorectal cancer patients in everyday practice.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test new therapies. Results may take years and might not lead to immediate changes in care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 50,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2013
- Expected to finish
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Jan 2051
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All patients diagnosed with colorectal, small bowel and anal cancer, who are recently diagnosed, have a strong suspicion without pathological confirmation or are currently under treatment or follow up in one of the participating hospitals will be asked to participate in this cohort study.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Histological proof of colorectal, small bowel and anal cancer, or a strong suspicion after imaging. * Informed consent for longitudinal observational data collection. Exclusion Criteria: * Mentally incompetent patients. Participation of patients to the PLCRC project does not exclude participation in any other ongoing or future study.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Anal cancer are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
70 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Locations
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Admiraal De Ruyter Ziekenhuis
RECRUITINGGoes, Netherlands
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Albert Schweitzer Ziekenhuis
RECRUITINGDordrecht, Netherlands
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Alrijne
RECRUITINGLeiden, Netherlands
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Amphia ziekenhuis
RECRUITINGBreda, Netherlands
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Anna Ziekenhuis
RECRUITINGGeldrop, Netherlands
Contact Email: •••••@•••••
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Antoni van Leeuwenhoek
RECRUITINGAmsterdam, Netherlands
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Antonius Ziekenhuis
RECRUITINGSneek, Netherlands
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Bernhoven
RECRUITINGOss, Netherlands
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Bravis ziekenhuis
RECRUITINGRoosendaal, Netherlands
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Canisius Wilhelmina Ziekenhuis
RECRUITINGNijmegen, Netherlands
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Catharina Ziekenhuis
RECRUITINGEindhoven, Netherlands
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Deventer Ziekenhuizen
RECRUITINGDeventer, Netherlands
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Diakonessenhuis
RECRUITINGUtrecht, Netherlands
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Dijklander Ziekenhuis
RECRUITINGHoorn, Netherlands
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Elisabeth-TweeSteden Ziekenhuis
RECRUITINGTilburg, Netherlands
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Elkerliek Ziekenhuis
RECRUITINGHelmond, Netherlands
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Erasmus MC
RECRUITINGRotterdam, Netherlands
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Flevoziekenhuis
RECRUITINGAlmere Stad, Netherlands
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Franciscus Gasthuis & Vlietland
RECRUITINGRotterdam, Netherlands
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Frisius MC Heerenveen
RECRUITINGHeerenveen, Netherlands
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Frisius MC Leeuwarden
RECRUITINGLeeuwarden, Netherlands
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Gelre Ziekenhuizen
RECRUITINGApeldoorn, Netherlands
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Groene Hart Ziekenhuis
RECRUITINGGouda, Netherlands
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Haaglanden MC
RECRUITINGThe Hague, Netherlands
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HagaZiekenhuis
RECRUITINGThe Hague, Netherlands
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IJsselland Ziekenhuis
RECRUITINGCapelle aan den IJssel, Netherlands
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Ikazia Ziekenhuis
RECRUITINGRotterdam, Netherlands
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Isala
RECRUITINGZwolle, Netherlands
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Jeroen Bosch Ziekenhuis
RECRUITING's-Hertogenbosch, Netherlands
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Laurentius Ziekenhuis
RECRUITINGRoermond, Netherlands
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Leids Universitair Medisch Centrum
RECRUITINGLeiden, Netherlands
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MAASTRO
RECRUITINGMaastricht, Netherlands
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Maasstad Ziekenhuis
RECRUITINGRotterdam, Netherlands
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Maastricht UMC+
RECRUITINGMaastricht, Netherlands
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Maasziekenhuis Pantein
RECRUITINGBeugen, Netherlands
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Martini Ziekenhuis
RECRUITINGGroningen, Netherlands
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Maxima Medisch Centrum
RECRUITINGEindhoven, Netherlands
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Meander Medisch Centrum
RECRUITINGAmersfoort, Netherlands
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Medisch Spectrum Twente
RECRUITINGEnschede, Netherlands
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Noordwest Ziekenhuisgroep
RECRUITINGAlkmaar, Netherlands
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OLVG
RECRUITINGAmsterdam, Netherlands
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Ommelander Ziekenhuis
RECRUITINGGroningen, Netherlands
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Radboud UMC
RECRUITINGNijmegen, Netherlands
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Reinier de Graaf
RECRUITINGDelft, Netherlands
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Rijnstate
RECRUITINGArnhem, Netherlands
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Rivas Beaterix Ziekenhuis
RECRUITINGGorinchem, Netherlands
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Rode Kruis Ziekenhuis
RECRUITINGBeverwijk, Netherlands
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Saxenburgh Groep
RECRUITINGHardenberg, Netherlands
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Slingeland Ziekenhuis
RECRUITINGDoetinchem, Netherlands
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Spaarne Gasthuis
RECRUITINGHaarlem, Netherlands
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St. Antonius ziekenhuis
RECRUITINGNieuwegein, Netherlands
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St. Jans Gasthuis
RECRUITINGWeert, Netherlands
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St.Jansdal
RECRUITINGHarderwijk, Netherlands
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Streekziekenhuis Koningin Beatrix
RECRUITINGWinterswijk, Netherlands
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Tergooi
RECRUITINGHilversum, Netherlands
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Treant Zorggroep
RECRUITINGHoogeveen, Netherlands
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UMC Groningen
RECRUITINGGroningen, Netherlands
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UMC Utrecht
RECRUITINGUtrecht, Netherlands
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VUmc
RECRUITINGAmsterdam, Netherlands
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Van Weel-Bethesda Ziekenhuis
RECRUITINGDirksland, Netherlands
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VieCuri Medisch Centrum
RECRUITINGVenlo, Netherlands
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Wilhelmina Ziekenhuis Assen
RECRUITINGAssen, Netherlands
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Zaans Medisch Centrum
RECRUITINGZaandam, Netherlands
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Ziekenhuis Amstelland
RECRUITINGAmstelveen, Netherlands
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Ziekenhuis Gelderse Vallei
RECRUITINGEde, Netherlands
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Ziekenhuis Nij Smellinghe
RECRUITINGDrachten, Netherlands
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Ziekenhuis Rivierenland
RECRUITINGTiel, Netherlands
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Ziekenhuisgroep Twente
RECRUITINGHengelo, Netherlands
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ZorgSaam
RECRUITINGTerneuzen, Netherlands
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Zuyderland Medisch Centrum
RECRUITINGSittard, Netherlands
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gut bacteria may hold clues to why some cancer treatments work better
- Burning the edges: a new way to stop colon polyps from coming back
- Missed Follow-Up colonoscopies: do they raise the risk of advanced growths?
- A 2.2 mm scope could spot cancerous tissue in minutes, not days
- The gatekeepers of tumors: scientists probe how blood vessels let immune cells in
- New Antibody-Drug conjugate put to the test against Hard-to-Treat cancers