Shiver away diabetes? new study tests cold therapy for blood sugar control

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients are able to provide signed and dated written informed consent prior to any study specific procedures * Women are post-menopausal (defined as at least 1 year post cessation of menses) * Aged ≥ 40 years and ≤ 75 years * Patients should have suitable veins for cannulation or repeated venipuncture * Body mass index (BMI) 25-38 kg/m2 * Stable dietary habits (no weight loss or gain \>5kg in the past 3 months) * Diagnosed with T2D at least 1.5 years before the start of the study * Relatively well-controlled T2D: HbA1c \< 8.5% * Oral glucose-lowering medication: metformin alone or in combination with sulfonylurea agents and/or on stable dose of a DPPIV inhibitor treatment for at least the last 3 months. In case of GLP-1 agonist medication treatment inclusion will be discussed with the dependent physician. * No signs of active diabetes-related co-morbidities like active cardiovascular diseases, active diabetic foot, polyneuropathy or retinopathy * No signs of active liver or kidney malfunction Exclusion Criteria: * Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator * Participate in sports of physical activity at a moderate- to high-intensity more than 3 times a week, or as judged by the investigator * Being cold-acclimated, e.g. having taken daily extended cold baths, working in a refrigerated environment, or practicing regular cold-water swimming/ showering within 1 month of starting the study * Unstable body weight (weight gain or loss \> 5 kg in the last three months) * Alcohol consumption of \>2 servings per day for man and \>1 servings per day for women * Smoking * Being insulin-dependent and/or using SGLT2 inhibitor medications * Patients with congestive heart failure and and/or severe renal and or liver insufficiency * Men: Hb \<8.4 mmol/L, Women: Hb \<7.8 mmol/l * A medical doctor will judge participation eligibility based on the medical history questionnaire, medication use and fasting blood parameters. If the medical doctor advises that a patient cannot participate, the patient will be excluded from enrolment. * Being pregnant * Having participated in another study involving PET/CT scanning in the past 1 year