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Can a cold brace ease pain after knee replacement?

NCT ID NCT05572359

Symptom relief Sponsor: Martini Hospital Groningen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using a cold and compression brace for six weeks after knee replacement surgery helps reduce pain and the need for painkillers. 208 patients who had a total or partial knee replacement were asked to use the brace five times a day for up to 20 minutes. Researchers compared their recovery to patients who received usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryo-and compression brace
What this could lead to
If it works, this could provide a simple, drug-free way to manage pain and improve recovery after knee replacement surgery.
What could go wrong
This is a completed trial, but the results are not yet widely known. The brace may not significantly reduce pain or opioid use compared to usual care, and individual results may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

208 people

The number who actually took part.

Started

May 2023

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for a primary TKA or UKA in the Martini Hospital. * Age ≥ 18 years Exclusion Criteria: * per-operative switch from UKA to TKA (only applicable for the UKA patients), * revision TKA implant (only applicable for the TKA patients), * rheumatoid arthritis, * other co-morbidities on which cooling may have a negative effect on (based on judgement of the orthopaedic surgeon), * inability to read and understand the Dutch language. Because the cool pack needs to be cooled in a freezer, it is required that a patient or the nursing home has a freezer that can be used.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis knee

Contacts and locations

Locations

  • Martini ziekenhuis

    Groningen, Provincie Groningen, 9728NT, Netherlands

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