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Prostate surgery showdown: which one is safer for your brain?

NCT ID NCT07468084

Knowledge-focused Sponsor: Cengiz Canakci, MD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 132 men aged 55-80 who had surgery for an enlarged prostate. Researchers compared two common procedures—HoLEP and TURP—to see if one affects memory and thinking more than the other. Participants took thinking tests before surgery and three months after. The goal is to help doctors choose the best surgery for each patient.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study shows one surgery is better for brain health, it could help doctors choose the safest option for men with enlarged prostates.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

132 people

The number who actually took part.

Started

Jul 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing surgical treatment for symptomatic BPH at a tertiary urology center.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male patients aged 55-80 years * Symptomatic benign prostatic hyperplasia requiring surgery * Prostate volume 50-100 cc * Baseline MMSE ≥ 24 * Ability to complete cognitive tests independently Exclusion Criteria: * Neurodegenerative diseases (Alzheimer's, Parkinson's) * History of cerebrovascular accident with deficits * Traumatic brain injury * Severe psychiatric disorders * Alcohol or substance abuse Chronic sedative or antipsychotic use * Severe visual or auditory impairment * Previous prostate surgery * Active malignancy * Perioperative complications requiring ICU admission

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Conditions

The condition(s) this trial relates to.

benign prostatic hyperplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Benign prostatic hyperplasia Cognitive functions

Contacts and locations

Locations

  • Health Science University Kartal Dr. Lütfi Kırdar City Hospital

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.