Coenzyme Q10 may boost IVF success in women with poor ovarian response

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals seeking IVF-ET fertility treatment; * Meeting the Bologna criteria for the definition of poor ovarian response (POR), specifically: * (1) Meeting 2 of the following 3 criteria: * ① Presence of high-risk factors for POR; * ② Previous cycle with ≤3 retrieved oocytes under a standard stimulation protocol; * ③ Abnormal ovarian reserve assessment: Antral follicle count (AFC) \<5 or Anti-Müllerian hormone (AMH) \<1.1 ng/mL. or * (2) Patients with normal age or ovarian reserve function who experience poor ovarian response (POR) after two consecutive cycles of maximum ovarian stimulation protocols; * BMI between 18.5-28.0 kg/m² * Voluntarily participate and sign an informed consent form. Exclusion Criteria: * Age ≥40 years; * Baseline FSH \>25 U/L; * Endocrine disorders (e.g., diabetes, thyroid disease) or autoimmune diseases (e.g., rheumatoid arthritis, lupus, Crohn's disease), chromosomal abnormalities, uterine malformations; * History of ovarian surgery; history of uterine surgery; adenomyosis; * History of more than 3 cycles of controlled ovarian stimulation (COS); * Male infertility; * Use within the past 3 months of medications that may affect ovarian reserve or ovarian responsiveness (e.g., oral contraceptives, glucocorticoids, antioxidant supplements, insulin sensitizers, DHEA, growth hormone, etc.); * Use of traditional Chinese medicine within the past 3 months; * Known allergy to Coenzyme Q10 or panthenol (water-soluble isomer of CoQ10); * PGT (Preimplantation Genetic Testing) population; * Acute or chronic renal insufficiency, hemodialysis treatment, history of severe renal impairment; * Infectious diseases such as HIV, active hepatitis, history of metabolic acidosis, tuberculosis; * Cardiovascular events within 3 months: coronary artery disease/myocardial infarction/clinically significant congestive heart failure; stroke/transient ischemic attack; deep vein thrombosis/pulmonary embolism; uncontrolled hypertension (systolic ≥160 mmHg or diastolic ≥90 mmHg); diagnosed diabetes; coronary intervention or coronary artery bypass graft surgery; * Neurological disorders such as dementia (e.g., Alzheimer's/Parkinson's) or use of related medications; * History of psychological/psychiatric disorders and use of antiepileptic, antidepressant, or similar medications; * History of cancer, radiation therapy, or chemotherapy; * Unwillingness to take supplements provided by this study; * Alcoholics, smokers, or individuals with substance dependence; * Participants in other clinical trials within the past month; * Patients deemed ineligible for enrollment by the investigator.