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Brain scan study aims to decode nocardiosis recovery

NCT ID NCT07013006

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study will review medical records of 60 people treated for brain nocardiosis, a rare infection. Researchers want to see how brain lesions change on MRI or CT scans during treatment and whether those changes relate to patient outcomes. The goal is to better understand what recovery looks like on scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand how brain lesions from nocardiosis change with treatment, potentially guiding future monitoring and care.
What could go wrong
This is a small, retrospective study that only looks back at medical records, so it cannot prove cause and effect. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient with cerebral nocardiosis and cared at an Assistance Publique -Hôpitaux de Paris hospital between 01/01/2004 and 01/12/2024.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Minor or adult patient with cerebral nocardiosis, defined by the presence of compatible clinical and radiological signs associated with the detection of Nocardia spp. in a biological sample (cerebral or extracerebral). * With available imaging tests: * All patients with 3 brain imaging tests at the 3 stages of treatment: within 2 weeks of diagnosis, upon transition to maintenance treatment (3-6 weeks after the start of treatment), and at the end of treatment (between 1 month before and 1 month after the end of antibiotic treatment). MRI scans are preferred; in the absence of MRI images, contrast-enhanced CT scans will be included. * OR: any patient who has undergone an MRI and a contrast-enhanced CT scan within two weeks of diagnosis, with the two tests performed within 72 hours of each other. * OR: any patient with a multimodal brain MRI at any time during infection, preferably within one month of diagnosis. Exclusion Criteria: * Refusal or impossibility of information.

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Conditions

The condition(s) this trial relates to.

nocardiosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nocardiosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Ambroise-Paré

    Boulogne-Billancourt, 92100, France

  • Hôpital Armand-Trousseau

    Paris, 75012, France

  • Hôpital Avicenne

    Bobigny, 93000, France

  • Hôpital Beaujon

    Clichy, 92110, France

  • Hôpital Bichat - Claude-Bernard

    Paris, 75018, France

  • Hôpital Bicêtre

    Le Kremlin-Bicêtre, 94270, France

  • Hôpital Cochin

    Paris, 75014, France

  • Hôpital Européen Georges-Pompidou, HEGP

    Paris, 75015, France

  • Hôpital Mondor

    Créteil, 94000, France

  • Hôpital Necker-Enfants Malades

    Paris, 75015, France

  • Hôpital Necker-Enfants Malades

    Paris, 75015, France

  • Hôpital Pitié-Salpêtrière

    Paris, 75013, France

  • Hôpital Saint-Antoine

    Paris, 75012, France

  • Hôpital Saint-Louis- Hôpital Lariboisière

    Paris, 75010, France