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Timing is everything: brain zap study seeks best moment to wake awareness

NCT ID NCT03810079

Knowledge-focused Sponsor: University of Liege Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving a mild brain stimulation (tDCS) when patients are more alert can improve their level of consciousness. Sixteen adults in a minimally conscious state took part. Researchers used EEG brainwave readings to pick the best time of day for stimulation and measured changes in awareness and brain activity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Aug 2019

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * CNS medication stable for at least a week, * Stable diagnosis of MCS (no diagnosis change based on 2 CRS-R performed within 1 week). * Adult (16 years old - 75 years old) * \> 28 days post injury Exclusion Criteria: * open craniotomies, * VPS under the stimulated area (prefrontal cortex), * pacemaker, * metallic cerebral implant, according to safety criteria for transcranial electric stimulation, * severe medical conditions that might influence clinical diagnosis and EEG activity (e.g., severe hepatic insufficiency or renal failure, or sub-continuous or abundant epileptiform discharges on standard EEG recordings).

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Conditions

The condition(s) this trial relates to.

Consciousness Disorders Persistent Vegetative State

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Minimally conscious state

Contacts and locations

Locations

  • University Hospital of Liege

    Liège, Liege, 4000, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.