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Could a diabetes drug boost fertility in PCOS? new trial tests combo therapy

NCT ID NCT07462065

Disease control Sponsor: PAEC General Hospital, Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 4 trial tests whether adding pioglitazone (a diabetes drug) to standard clomiphene citrate improves ovarian stimulation and pregnancy rates in 62 infertile women with polycystic ovary syndrome (PCOS). Participants are randomly assigned to receive either pioglitazone or a placebo alongside clomiphene, and follicle growth is tracked via ultrasound. The study aims to see if the combination leads to more mature eggs and higher pregnancy rates.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
clomiphene citrate and pioglitazone
What this could lead to
If successful, this could show that adding pioglitazone to clomiphene improves ovarian stimulation and pregnancy rates in women with PCOS.
What could go wrong
This is a small Phase 4 trial with only 62 participants, so results may not apply to all women. Side effects like swelling, fluid retention, and weight gain are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 38 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Normal hysterosalpingography Normal spermogram Suffering from PCOS Ovarian cysts less than 20mm. Exclusion Criteria: History of chronic cardiovascular disease Chronic kidney disease Diabetes Thyroid disease Pulmonary disease

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility treatment Pregnancy rates

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Pakistan Atomic Energy Commission Hospital

    RECRUITING

    Islamabad, Federal, 44000, Pakistan

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