Could a single daily antibiotic dose be enough for septic abortion?
NCT ID NCT02309346
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving the antibiotic clindamycin once a day (along with gentamicin) works as well as the standard three-times-a-day regimen for treating septic abortion, a serious infection after a miscarriage or abortion. Researchers enrolled 202 women and measured cure rates, defined as reduced pain, bleeding, and no fever for 48 hours. The goal was to see if a simpler dosing schedule could be just as effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Clindamycin and gentamicin (antibiotics given intravenously)
- What this could lead to
- If successful, this could simplify treatment for septic abortion by showing that a once-daily antibiotic dose works as well as the standard three-times-a-day regimen.
- What could go wrong
- This is a completed phase 4 trial, but results may not apply to all patients or settings. The definition of cure is based on clinical signs, and some patients were lost to follow-up, which could affect reliability.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
202 people
The number who actually took part.
- Started
-
Dec 2014
- Finished
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Dec 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 50 years
- Sex
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Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women with clinical diagnosis of septic abortion: Briefly, a suspicion of infected/septic abortion was confirmed by the presence of at least one of the following clinical signs: a history of intrauterine manipulation with contaminated objects; foul-smelling vaginal discharge; purulent discharge from the cervix; signs of peritoneal irritation; leukocytosis (leukocyte count \> 14,000/mL); fever (temperature ≥ 37.8°C); or signs of a systemic inflammatory response, including tachycardia (heart rate \> 110 bpm), tachypnoea (respiratory rate \> 30 breaths/min), arterial hypotension (systolic blood pressure \< 90 mmHg), oliguria, cyanosis, or pallor. Exclusion Criteria: * Refuse to participate in the study * Use of antibiotics with 1 week prior randomization * Known allergy to clindamycin or gentamycin
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-003, Brazil