New study tests if a liquid diet can prevent dangerous aspiration in patients on popular diabetes drugs
NCT ID NCT06654219
First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 3 times
Summary
This study looks at whether a clear liquid diet for 24 hours before anesthesia can reduce leftover stomach contents in patients taking GLP-1 drugs (like Ozempic). These drugs slow digestion, which can increase the risk of food or liquid entering the lungs during anesthesia. The study will compare two groups: one that follows the liquid diet and one that fasts normally. Researchers will measure stomach contents using ultrasound and check for side effects like thirst and hunger.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- clear liquid diet
- What this could lead to
- If successful, this could lead to safer fasting guidelines for patients on GLP-1 drugs before procedures, reducing the risk of lung aspiration.
- What could go wrong
- This is a small, early-phase study (136 participants) that only measures stomach contents, not actual aspiration events. Results may not apply to all patients or procedures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 136 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients taking Glucagon Like Peptide-1 Receptor (GLP-1 RA) agonists * Undergoing upper endoscopy only - no colonoscopy due to prep Exclusion Criteria: * Previous gastric resection or bypass * Gastric band in situ * Previous fundoplication * Large hiatal hernia * Pregnant patients * Recent trauma * Inability to turn to the right lateral decubitus position. * Patients on erythromycin, metoclopramide, domperidone, opioids. * Gastroparesis previous
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States
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