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New microscope technique aims to sharpen diagnosis of mysterious chest fluid

NCT ID NCT06741839

Diagnosis Sponsor: China-Japan Friendship Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using a special microscope (confocal laser endomicroscopy) during a chest camera procedure can better diagnose unexplained pleural disease. About 158 adults with fluid around the lungs that standard tests couldn't diagnose will be randomly assigned to get either the microscope-guided biopsy or the usual visual biopsy. The goal is to see if the microscope helps doctors make a more accurate diagnosis and possibly take fewer tissue samples.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
confocal laser endomicroscopy (a special microscope used during a chest procedure)
What this could lead to
If successful, this could make diagnosing hard-to-identify pleural diseases more accurate and reduce the number of biopsies needed.
What could go wrong
This is a relatively small, early-stage trial. The new technique may not improve diagnosis enough to justify its use, and there are standard risks from the chest procedure itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 158 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years; * Evidence of exudative pleural effusion in which a specific diagnosis could not be determined using clinical, radiological, laboratory, or cytological examinations * Willingness to participate in the study and undergo an invasive procedure.; Exclusion Criteria: * Pleural thickening or pleural-based mass without pleural effusion on radiologic examination; * Hemodynamic instability; * Presence of parapneumonic effusion; * Any contraindication to pleural biopsy or semirigid thoracoscopy; * Participation in other studies within three months without withdrawal or termination.

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Conditions

The condition(s) this trial relates to.

pleural disorder Pleural Effusion pleurisy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pleural diseases Pleural effusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • China-Japan Friendship Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100029, China

More trials for these conditions

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