Does surgery spread cervical cancer cells? new study investigates
NCT ID NCT04770090
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether surgery for early-stage cervical cancer causes tumor cells to enter the bloodstream, which might explain higher recurrence rates seen with certain surgical methods. Researchers will take blood samples from 20 women during their operation to detect circulating tumor cells. They will also track whether these women remain cancer-free for 3 to 5 years after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If tumor cells are found in the blood during surgery, it could help explain why some women have a higher risk of cancer returning after certain types of surgery.
- What could go wrong
- This is a small, early-stage observational study, so it may not prove that these cells cause recurrence. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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200 people
The number who actually took part.
- Started
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Mar 2022
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Woman \>18 years old * Cervical cancer confirmed by histology * Early stage eligible for immediate surgical treatment (or post-brachytherapy): stages IA1, 1A2, 1B1 and IB2 with or without emboli determined by MRI performed as part of the treatment * Histology : epidermoid carcinoma and adenocarcinoma * Valid Social Security * Wrote consent Exclusion Criteria: * Advanced stage (Stage IB3 and more) * Concomitant cancer * Pregnant or breastfeeding woman * Vulnerable person (Article L1121-6 of the Public Health Code) * Participation to other study with an exclusion period still in progress * Participation to other study that may have an impact on the prognosis of cervical cancer
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Nîmes
Nîmes, France
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Department of gynaecology, Montpellier University Hospital
Montpellier, 34295, France
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Institut du Cancer de Montpellier - Val d'Aurelle
Montpellier, 34298, France
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