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New sedation drug ciprofol tested against propofol for safer anesthesia in seniors

NCT ID NCT07670923

Symptom relief Sponsor: General Hospital of Ningxia Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 20, 2026 · Updated 2 times

Summary

This study compares ciprofol and propofol, two drugs used to sedate elderly patients (ages 65-80) during short medical procedures without a breathing tube. Researchers will monitor heart rate, blood pressure, and breathing for 5 minutes after giving the drug. The goal is to see which drug causes fewer side effects on the heart and lungs. 108 participants will be enrolled at a single hospital in China.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ciprofol and propofol
What this could lead to
If ciprofol proves safer for heart and lung function, it could become a preferred sedation option for elderly patients undergoing short procedures.
What could go wrong
This is a small, early-phase trial (108 participants) comparing two drugs, so results may not apply broadly. Both drugs carry risks like low blood pressure or breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients scheduled for elective non-intubated general anesthesia 2. Age ranging from 65 to 80 years old 3. American Society of Anesthesiologists (ASA) physical status class I-III 4. Written informed consent signed by the patient or legal guardian Exclusion Criteria: 1. Confirmed allergy to propofol, ciprofol or their excipients 2. Severe cardiovascular diseases (uncontrolled hypertension, heart failure, severe arrhythmia, etc.) 3. Severe respiratory diseases (chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, etc.) 4. Severe hepatic or renal insufficiency 5. Long-term regular use of sedatives or opioids 6. Baseline bradycardia (HR \< 50 beats/min) or hypoxemia (SpO₂ \< 90%)

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Conditions

The condition(s) this trial relates to.

Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Comparison of hemodynamics and respiratory function between ciprofol and propofol in elderly patients undergoing non-intubated general anesthesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University

    RECRUITING

    Yinchuan, Ningxia, 750000, China