New sedative ciprofol may be safer for emergency intubation in ICU
NCT ID NCT06344949
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether ciprofol, a newer sedative, causes fewer drops in blood pressure than the standard drug propofol when ICU patients need an emergency breathing tube. About 100 critically ill adults will receive one of the two drugs before intubation. The goal is to find a safer sedation method for these high-risk procedures.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ciprofol
- What this could lead to
- If ciprofol proves safer, it could offer a more stable sedation option for emergency intubations in the ICU, reducing complications like low blood pressure.
- What could go wrong
- This is a small pilot study with only 100 patients, so results may not apply broadly. The drug is new and its advantages over propofol are not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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100 people
The number who actually took part.
- Started
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Nov 2024
- Finished
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Oct 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who need to undergo tracheal intubation under sedation after entering the ICU; * Age range from 18 to 85 years old; * Patients or their families have a full understanding of the purpose and significance of this trial, voluntarily participate in this clinical trial, and sign an informed consent form. Exclusion Criteria: * Patients who are allergic to the study drugs, or patients with contraindications to the study drugs; * Patients with difficult airways (MACOCHA ≥ 3 points); * Patients who require emergency intubation due to sudden cardiac arrest; * Patients who require conscious intubation; * Patients who can maintain mean arterial pressure (MAP) above 65mmHg using of one or more vasoactive drugs (equivalent (-)-noradrenaline \> 0.3 μg kg min); * In a state of imminent death; * Pregnant and/or lactating women; Subject judged by the investigator to have any other factors unsuitable for participation in the study
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhongshan Hospital Affiliated to Fudan University
Shanghai, Shanghai Municipality, 200032, China