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New anesthetic may keep blood pressure steadier during surgery in older adults

NCT ID NCT06952608

Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether ciprofol, a newer anesthetic, causes fewer dangerous blood pressure drops during surgery compared to the standard drug propofol. It involves 140 elderly patients (65+) who take blood pressure medications and are having abdominal surgery. The goal is to see if ciprofol can help prevent complications like organ damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ciprofol
What this could lead to
If ciprofol works better, it could reduce dangerous blood pressure drops during surgery in older adults, potentially lowering the risk of organ damage and death.
What could go wrong
This is a small, early-phase trial (140 people) comparing two anesthetics, so results may not apply broadly. Ciprofol is new, and its safety profile is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients undergoing elective abdominal surgery under general anesthesia 2. Duration of surgery exceeding 2 hours 3. Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery) 4. Age ≥ 65 years 5. ASA classification II-III 6. Informed consent was obtained from patients or their guardians Exclusion Criteria: 1. History of allergy to opioids, propofol, or ciprofol components. 2. Anticipated difficult airway (limited mouth opening, restricted neck movement, or modified Mallampati grade III-IV) or difficult mask ventilation. Body mass index ≤18 or ≥35 kg/m². 3. Severe hepatic dysfunction (total bilirubin ≥3.0 mg/dL or AST/ALT ≥2 times the upper limit of normal). 4. Severe renal impairment (creatinine clearance ≤30 mL/min). 5. Cardiac diseases (AV block higher than first-degree, heart rate \<50 bpm, severe arrhythmias, severe valvular heart disease, heart failure, or unstable angina on the day of surgery). 6. Preoperative cognitive impairment, cerebrovascular disease, or history of psychiatric illness. 7. Abnormal thyroid-stimulating hormone levels or history of thyroid replacement therapy. 8. Unstable asthma or history of asthma. 9. Alcohol abuse, drug abuse, chronic opioid dependence, or analgesic use exceeding 3 months. 10. Lactating or pregnant women.

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Conditions

The condition(s) this trial relates to.

channelopathy-associated congenital insensitivity to pain, autosomal recessive

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ciprofol Intraoperative hypotension Renin-angiotensin system inhibitors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Second Affiliated Hospital of Zhejiang University anesthesiology department

    RECRUITING

    Hangzhou, Zhejiang, 310000, China

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