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New anesthetic may protect frail elderly from dangerous blood pressure drops during surgery

NCT ID NCT07663695

Disease control Sponsor: General Hospital of Ningxia Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether a newer anesthetic drug, ciprofol, causes fewer dangerous drops in blood pressure during anesthesia than the standard drug propofol in frail patients aged 60 and older having major abdominal surgery. Participants are randomly assigned to receive one of the two drugs, and researchers monitor blood pressure closely. The goal is to find a safer option for this vulnerable group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ciprofol and propofol
What this could lead to
If ciprofol causes fewer dangerous drops in blood pressure, it could become a safer choice for anesthesia in frail older patients.
What could go wrong
This is a small, single-center trial. Results may not apply to all frail elderly patients, and ciprofol may not prove safer than propofol.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 96 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled to undergo major abdominal surgery under general anesthesia. * Frailty score \>= 3\[cite: 2\]. * Age \>= 60 years\[cite: 2\]. * American Society of Anesthesiologists (ASA) physical status class \>= II\[cite: 2\]. * Planned invasive blood pressure monitoring\[cite: 2\]. Exclusion Criteria: * Severe cardiac arrhythmia\[cite: 2\]. * Severe valvular heart disease\[cite: 2\]. * Poorly controlled hypertension with medication (systolic blood pressure \>= 180 mmHg and/or diastolic blood pressure \>= 110 mmHg)\[cite: 2\]. * Pre-existing preoperative hypotension (mean arterial pressure \< 65 mmHg)\[cite: 2\]. * Preoperative renal dysfunction (serum creatinine greater than the upper limit of normal)\[cite: 2\].

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypotension

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, 750000, China

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