Which therapy restores hand function after stroke? a Head-to-Head trial
NCT ID NCT07764939
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial compares two rehabilitation approaches—constraint-induced movement therapy (CIMT) and task-oriented training (TOT)—to see which better improves hand function in people recovering from a stroke. About 48 adults aged 45–65 who had a stroke more than three months ago will be randomly assigned to one of the two therapies, attending 15 sessions over three weeks. Researchers will measure hand dexterity and grip strength using standard tests to determine which therapy offers greater benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Constraint-Induced Movement Therapy (CIMT) and Task-Oriented Training (TOT)
- What this could lead to
- If one therapy proves more effective, it could guide rehabilitation programs to help stroke survivors regain hand function more efficiently.
- What could go wrong
- The trial is small (48 participants) and early, so results may not apply to all stroke patients. Both therapies require intensive effort, and individual outcomes can vary.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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48 people
The number who actually took part.
- Started
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Jul 2025
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants will be included if they meet the following criteria: * Age between 45 and 65 years * Both male and female participants * First-ever unilateral ischemic or hemorrhagic stroke confirmed by imaging * Stroke onset in subacute to chronic phase (\>3 months post-stroke) * Medically stable and able to sit independently * Voluntary wrist extension of at least 10 degrees and finger extension of at least 10 degrees in the affected hand * Mini-Mental State Examination (MMSE) score \> 26 * No significant pain or spasticity in affected upper limb (Modified Ashworth Scale \< 2) * Adequate sitting balance and trunk control for upper limb activities * Willingness and availability to complete the full intervention (3 weeks) * No significant musculoskeletal impairments (e.g., fractures or arthritis) affecting the upper limb Exclusion Criteria: Participants will be excluded if they have: * Severe spasticity (Modified Ashworth Scale \> 3) or joint contractures * Severe aphasia, neglect, or cognitive impairments affecting task performance * Recurrent or bilateral stroke * Severe upper limb impairment * Joint contractures or orthopedic limitations in the upper limb * Active infections, skin lesions, or wounds on the upper limb * Severe pain during limb movement * Participation in other upper limb rehabilitation programs concurrently
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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department of physiotherapy, Allama Iqbal Memorial Teaching Hospital
Sialkot, Punjab Province, 51310, Pakistan
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Other studies related to the condition(s) this trial covers.