Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Choline pill may harm arteries, small study hints

NCT ID NCT03646175

Knowledge-focused Sponsor: Virginia Polytechnic Institute and State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether taking a choline supplement (1000 mg) the night before affects blood vessel function in 29 healthy adults. Participants took either choline or a placebo, then had their artery function measured. The goal was to see if choline, which raises a gut-related compound called TMAO, could impair vascular health. Results may help understand links between diet and heart disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
choline (dietary supplement)
What this could lead to
If it works, this could help explain how choline from diet or supplements might affect heart health.
What could go wrong
This is a small, short-term study in healthy people, so results may not apply to everyone or predict long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

29 people

The number who actually took part.

Started

Sep 2018

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-65 years old * Healthy * Non-smoking * Weight stable for previous 6 months (±2.0 kg) * BMI \<35 kg/m\^2 * Verbal and written informed consent * Approved for participation by study medical director (Jose Rivero, M.D.) Exclusion Criteria: * Smoking * Pregnancy * Obese (BMI\>35 kg/m2) * Altered dietary patterns within the last month of recruitment * Unstable heart disease or diabetes * Untreated high blood pressure or high cholesterol * Allergies to choline * Unvaccinated against COVID-19

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Cardiovascular risk factor are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular risk factor

Contacts and locations

Locations

  • Virginia Polytechnic and State University

    Blacksburg, Virginia, 24060, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.