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Filler Face-Off: restylane lyft vs juvederm for a sharper chin

NCT ID NCT05777759

Symptom relief Sponsor: Galderma R&D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether Restylane Lyft with lidocaine is as safe and effective as Juvederm Voluma XC for improving a recessed chin. 175 adults received one of the two fillers, and doctors rated chin retrusion using a standard scale. The main goal was to see if Restylane Lyft worked as well as the comparator at 3 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Restylane Lyft with lidocaine (hyaluronic acid gel)
What this could lead to
If successful, this could offer a safe and effective option for people seeking to improve a recessed chin without surgery.
What could go wrong
This is a cosmetic study, not a treatment for a medical condition. Results may not apply to all chin shapes or skin types, and side effects like swelling or bruising are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

175 people

The number who actually took part.

Started

Mar 2023

Finished

Jul 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males or non-pregnant, non-breastfeeding females, 22 years of age or older * Intent to receive treatment for augmentation and correction of retrusion in the chin region. Exclusion Criteria: * Known/previous allergy of hypersensitivity to any injectable hyaluronic acid (HA) gel or gram-positive bacterial proteins. * Known/previous allergy or hypersensitivity to local anesthetics, e.g., lidocaine or other amide-type anesthetics. * Previous or present multiple severe allergies or severe allergies, such as manifested by anaphylaxis or angioedema or family history of angioedema. * Previous facial surgery (including facial aesthetic surgery and liposuction), below the level of the horizontal line from the subnasale. * Any previous aesthetic procedures or implants * Presence of any disease or lesion near or on the area to be treated.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chin augmentation Chin retrusion

Contacts and locations

Locations

  • Galderma Research Site

    Los Angeles, California, 90025, United States

  • Galderma Research Site

    Westport, Connecticut, 06880, United States

  • Galderma Research Site

    Aventura, Florida, 33180, United States

  • Galderma Research Site

    Coral Gables, Florida, 33143, United States

  • Galderma Research Site

    Alpharetta, Georgia, 30022, United States

  • Galderma Research Site

    Atlanta, Georgia, 30331, United States

  • Galderma Research Site

    Rockville, Maryland, 20852, United States

  • Galderma Research Site

    Chestnut Hill, Massachusetts, 02467, United States

  • Galderma Research Site

    Nashville, Tennessee, 37203, United States

  • Galderma Research Site

    Pflugerville, Texas, 78660, United States

  • Galderma Research Site

    San Juan, 00917, Puerto Rico

  • United States, California

    Manhattan Beach, California, 90266, United States

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