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New checklist aims to slash MRSA infections in veterans after surgery

NCT ID NCT02216227

Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a checklist to prevent MRSA surgical site infections in over 23,000 veterans undergoing joint replacement or heart surgery. The checklist included using antibiotic ointment and antiseptic baths before surgery, plus antibiotics during surgery. Researchers measured how many patients got MRSA infections within 90 days and within a year after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mupirocin, chlorhexidine gluconate, cefazolin, vancomycin
What this could lead to
If successful, this checklist could become a standard way to prevent serious surgical infections in veterans and other patients.
What could go wrong
The study is observational, not a randomized trial, so results may be influenced by other factors. The checklist may not work in all hospitals or for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23,005 people

The number who actually took part.

Started

Apr 2014

Finished

Feb 2021

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Retrospective Control Group Inclusion Criteria: * Patients identified in VA databases (e.g. VASQIP) by ICD-9 procedure codes as undergoing total joint arthroplasty or cardiac surgery at the 10 intervention VA Medical Centers during the 5 year preintervention period (2008-2013) Concurrent Non-equivalent Control Group Inclusion Criteria: * Patients identified in VA databases (e.g. VASQIP) by ICD-9 procedure codes as undergoing total joint arthroplasty or cardiac surgery at VA Medical Centers not included in the intervention group during the 8 years evaluated (5 years pre-intervention to match with the retrospective control group and 3 years of the intervention.) Exclusion Criteria: For All Patient Groups: * Have an ICD-9 diagnosis code consistent with endocarditis * Have any documented infection before the surgical procedure * Undergo cardiac transplants or cardiac procedures performed using the percutaneous or thoracotomy approach * Undergoing hip and knee revisions * Documented allergies to mupirocin

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection methicillin-resistant staphylococcus aureus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgical site infection

Contacts and locations

Locations

  • Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

    Baltimore, Maryland, 21201, United States

  • Iowa City VA Health Care System, Iowa City, IA

    Iowa City, Iowa, 52246-2208, United States

  • Miami VA Healthcare System, Miami, FL

    Miami, Florida, 33125, United States

  • Minneapolis VA Health Care System, Minneapolis, MN

    Minneapolis, Minnesota, 55417, United States

  • Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE

    Omaha, Nebraska, 68105-1873, United States

  • South Texas Health Care System, San Antonio, TX

    San Antonio, Texas, 78229, United States

  • VA Ann Arbor Healthcare System, Ann Arbor, MI

    Ann Arbor, Michigan, 48105, United States

  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

    Boston, Massachusetts, 02130, United States

  • VA Portland Health Care System, Portland, OR

    Portland, Oregon, 97239, United States

  • VA Salt Lake City Health Care System, Salt Lake City, UT

    Salt Lake City, Utah, 84148, United States

  • William S. Middleton Memorial Veterans Hospital, Madison, WI

    Madison, Wisconsin, 53705, United States

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