Tiny study hints at preterm birth risk after cervical procedure
NCT ID NCT03472066
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether the age at which a woman had a cervical conization (removal of precancerous tissue) affects the length of her cervix during a later pregnancy. A shorter cervix can raise the risk of preterm birth. Researchers measured cervix length in pregnant women who had conization and compared them to women who did not. The goal was to find an age cutoff below which conization might lead to a shorter cervix, helping doctors identify at-risk pregnancies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify women at higher risk for preterm birth after conization, allowing closer monitoring and preventive care.
- What could go wrong
- This is a very small, completed observational study with only 2 participants, so results may not apply broadly. It does not test a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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2 people
The number who actually took part.
- Started
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Oct 2018
- Finished
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Apr 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Including 84 evaluable patients for the primary endpoint would show a Pearson correlation of at least 0.3 between cervical size and age at conization. These calculations were carried out with a 5% risk of first bilateral species and 80% power. Taking into account the risk of incomplete data, we plan to include 90 patients. A control group of 90 patients will also be recruited.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patient referred since January 2008 with pregnancy between 2008 and 2017 2. Pregnancy after conisation 3. Cervix size between 21 and 24 SA before any obstetric event 4. Control group: parity matching, asymptomatic patients Exclusion Criteria: 1. Threat of late miscarriage, 2. Premature rupture of membranes before cervical echography, 3. Other pregnancies after study of 1st pregnancy after conisation, 4. No measurement of the conization specimen, 5. Lost to follow-up, 6. Age \<18 7. Twin Pregnancies 8. Patient under guardianship
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Amiens-Picardie
Amiens, 80054, France
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