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Cheaper brain monitoring method tested in liver transplants

NCT ID NCT07442214

Knowledge-focused Sponsor: Inonu University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two non-invasive methods for monitoring brain blood flow during liver transplant surgery: carotid Doppler ultrasound and near-infrared spectroscopy (NIRS). The goal is to see if the simpler, cheaper ultrasound can replace the more expensive NIRS. The study involves 43 adults undergoing elective liver transplantation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simpler, cheaper way to monitor brain blood flow during liver transplant surgery, improving patient safety.
What could go wrong
This is a small, early-stage study (43 participants) comparing monitoring methods, not testing a treatment. Results may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

43 people

The number who actually took part.

Started

Feb 2025

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients aged 18-65 years who underwent elective liver transplantation at Inonu University Turgut Ozal Medical Center. All participants had end-stage liver disease and were monitored intraoperatively for cerebral perfusion using carotid Doppler ultrasonography and near-infrared spectroscopy (NIRS). The study was conducted as a single-center, prospective observational study.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18-65 years scheduled for elective liver transplantation * Written informed consent obtained prior to participation Exclusion Criteria: * Fulminant hepatic failure * Hepatic encephalopathy * Hepatorenal or hepatopulmonary syndrome * Pre-existing cerebrovascular disease or carotid stenosis * Severe cardiopulmonary comorbidity * Refusal to participate

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Conditions

The condition(s) this trial relates to.

chronic liver failure End Stage Liver Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral perfusion End-stage liver disease (ESLD) Intraoperative monitoring Liver transplantation

Contacts and locations

Locations

  • Inonu University Turgut Ozal Medical Center.

    Malatya, Battalgazi, 44280, Turkey (Türkiye)

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