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Ancient herb gotu kola put to the test for healthier arteries in aging

NCT ID NCT06472791

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates whether a dietary supplement made from centella asiatica, also known as gotu kola, can improve the function of blood vessels in adults aged 50 to 85. Participants take either the herb or a placebo for four weeks, and researchers measure changes in blood vessel flexibility using a non-invasive finger device. The goal is to see if this traditional herb can help maintain vascular health as people age.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
centella asiatica (gotu kola) dietary supplement
What this could lead to
If it works, this could point toward a simple supplement to support blood vessel health and reduce age-related cardiovascular risk.
What could go wrong
This is a small, early-stage trial with only 23 participants. Results may not apply to everyone, and the supplement may show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

Feb 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ● Age 50 through 85, male or female * Sufficient proficiency in English to understand study purpose and directions * Willing and able to give informed consent * Able to follow protocol and attend visits Exclusion Criteria: * History of myocardial infarction, known coronary or carotid disease, or heart failure * History of stroke, Parkinson's disease, dementia, or other major CNS disorders * History of hepatic disease (e.g. hepatitis, cirrhosis) * Recent/recurring history of severe life-threatening medical conditions (e.g. cancer, except non-melanoma skin cancers) * Active major infectious disease (e.g. pneumonia) * Heavy alcohol use (15 drinks or more per week for men or 8 drinks or more per week for women) or substance use disorder * Current use of any medication typically used to treat hypertension or lower blood pressure (e.g. beta-blockers, ACE inhibitors) * Current use of any medication typically used to prevent the coagulation of blood (e.g. warfarin (Coumadin)) * Chronic NSAID use (\>3 times a week for more than 3 months) * Current use of any medication or supplement typically used as a sedative (e.g. zolpidem (Ambien), benzodiazepines (Valium, Xanax), valerian root) * Dietary supplements for improving nitric-oxide synthesis (e.g. L-arginine, L-citrulline) * Current use of any medication typically used to control hypoglycemia (e.g. biguanides (Metformin)) * Current use of any medication typically used for erectile dysfunction (e.g. sildenafil (Viagra), tadalafil (Cialis)) * Pregnant, nursing, or planning a pregnancy within the next 6 weeks * Open skin rashes and sores that may interfere with the placement of sensors

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Helfgott Research Institute

    Portland, Oregon, 97201, United States

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