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New drug aims to reverse heart damage in failure patients

NCT ID NCT06979375

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a potential new medicine called CDR132L in 200 people with heart failure and an enlarged heart. Participants receive either CDR132L or a placebo by IV every 4 weeks for 48 weeks. The goal is to see if the drug can improve heart structure and function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CDR132L (a potential new medicine given as an intravenous infusion every 4 weeks for 48 weeks)
What this could lead to
If it works, this could point toward a new treatment that improves heart structure and function in people with heart failure.
What could go wrong
This is a Phase 2 trial with only 200 participants, so it is still early. The drug may not show benefit over placebo, and there may be unknown side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 84 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 40-84 years (both inclusive) at the time of signing the informed consent. * Documented symptomatic heart failure (HF) diagnosed greater than or equal to (≥) 180 days prior to screening with at least weekly need for oral diuretic treatment, and New York Heart Association class II-III at screening. * Clinically stable and on optimized doses and unchanged drug classes of guideline-directed HF therapy ≥ 45 days prior to randomisation. * Left ventricular ejection fraction (LVEF) less than (\<) 50 percent (%) as assessed by echocardiography at screening, measured by central laboratory. * Left ventricular hypertrophy or left ventricular dilatation assessed by echocardiography at screening measured by central laboratory with any of the following: 1. LVMi greater than (\>)88 g/m\^2 for female participants and \>102 g/m\^2 for male participants using the truncated ellipsoid method. 2. LVMi \>95 g/m\^2 for female participants and \>115 g/m\^2 for male participants, using the linear method (cube formula). 3. Left ventricular end-diastolic diameter indexed to body surface area (LVEDDi) \>3.1 cm/m\^2 for female participants and \>3.0 cm/m\^2 for male participants. * Body mass index 18.5-40 kilogram per meter square (kg/m\^2) (both inclusive) and body weight less than or equal to (≤) 140 kilogram (kg). Body mass index is calculated in the electronic case report form based on height and body weight at the screening visit (visit 1). * N-terminal pro B-type natriuretic peptide (NT-proBNP) ≥ 300 picograms per milliliter (pg/mL); NT-proBNP ≥600 pg/mL if atrial fibrillation/flutter is present at time of screening, measured by central laboratory. Exclusion Criteria: * Estimated Glomerular Filtration Rate (eGFR) less than (\<) 30 milliliter/minute/ 1.73-meter square (mL/min/1.73 m\^2) at time of screening, measured by central laboratory. * Participants with an episode of acute kidney failure or acute kidney injury, at the discretion of the investigator,within 90 days prior to randomisation. * Myocardial infarction, unstable angina pectoris or HF hospitalization within 30 days prior to screening. * Participants receiving intravenous HF medications within 45 days prior to randomisation. * Planned coronary revascularization, pacemaker/cardioverter-defibrillator/cardiac resynchronization therapy (CRT) implantation, ablation of cardiac arrythmias or valve repair/replacement at the time of randomisation. * Stroke or transient ischemic attack within 12 months prior to randomisation. * Participants with potential disruption of the blood-brain barrier (e.g., multiple sclerosis), in the opinion of the investigator. * Known history of severe liver disease and/or alanine aminotransferase or aspartate aminotransferase greater than (\>) 2.5x upper limit of normal at screening, measured by central laboratory. * Known genetic (or highly suspected due to family history) cause of increased cardiac mass (including dilated cardiomyopathy, Fabry disease and likely pathogenic or pathogenic variants within hypertrophic cardiomyopathy (HCM). * Participants with suspected or diagnosed cardiac amyloidosis or sarcoidosis.

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    86 sites in 10 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ

    NOT_YET_RECRUITING

    Lublin, Lublin Voivodeship, 20-049, Poland

  • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

    RECRUITING

    Wroclaw, Lower Silesian Voivodeship, 50-981, Poland

  • American Heart of Poland S.A.

    NOT_YET_RECRUITING

    Bielsko-Biala, 43-316, Poland

  • AmsterdamUMC AMC

    RECRUITING

    Amsterdam, 1105 AZ, Netherlands

  • Arneja Heart & Multispeciality Hospital

    RECRUITING

    Nagpur, Maharashtra, 440010, India

  • Arneja Heart & Multispeciality Hospital

    NOT_YET_RECRUITING

    Nagpur, Maharashtra, 440010, India

  • Charité - Campus Benjamin Franklin - Klinik für Kardiologie

    NOT_YET_RECRUITING

    Berlin, 12203, Germany

  • Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)

    RECRUITING

    Berlin, 13353, Germany

  • Chungbuk National University Hospital

    RECRUITING

    Cheongju-si, 28644, South Korea

  • Concord Repatriation General Hospital - Cardiology Department

    RECRUITING

    Concord, New South Wales, 2139, Australia

  • Dayanand Medical College & Hospital

    RECRUITING

    Ludhiana, Punjab, 141001, India

  • Erasmus MC

    RECRUITING

    Rotterdam, 3015 GD, Netherlands

  • Fakultní Nemocnice Ostrava

    RECRUITING

    Ostrava-Poruba, 708 52, Czechia

  • Fakultní nemocnice u sv. Anny v Brně

    COMPLETED

    Brno, 602 00, Czechia

  • Fiona Stanley Hospital - Cardiology

    RECRUITING

    Murdoch, Western Australia, 6150, Australia

  • Flinders Medical Centre

    RECRUITING

    Bedford Park, South Australia, 5042, Australia

  • G B Pant Institute of Postgraduate Medical Education and Research

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110002, India

  • H. Clinico Univ. Virgen de la Victoria

    COMPLETED

    Málaga, 29010, Spain

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

  • Hospital Ramón y Cajal_Cardiología

    NOT_YET_RECRUITING

    Madrid, 28034, Spain

  • Hospital Univ. Virgen de la Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

  • Hospital Univ. de Gerona Doctor Josep Trueta

    RECRUITING

    Girona, Catalonia, 17007, Spain

  • Hospital Univ. de Gran Canaria Doctor Negrín

    NOT_YET_RECRUITING

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    NOT_YET_RECRUITING

    Majadahonda, 28222, Spain

  • Hospital Universitario San Cecilio

    RECRUITING

    Granada, Andalusia, 18016, Spain

  • Hospital Universitario Virgen del Rocío

    NOT_YET_RECRUITING

    Seville, 41013, Spain

  • Hospital Virgen de la Arrixaca

    NOT_YET_RECRUITING

    El Palmar, 30120, Spain

  • Hospital de Dénia_Cardiología

    COMPLETED

    Denia, 03700, Spain

  • Hospital del Mar

    RECRUITING

    Barcelona, 08003, Spain

  • Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology

    RECRUITING

    Himeji-shi, Hyogo, 670-8560, Japan

  • IKEM

    RECRUITING

    Prague, 140 21, Czechia

  • JA Shizuoka Kohseiren Enshu Hospital_ Cardiology

    NOT_YET_RECRUITING

    Hamamatsu-shi, Shizuoka, 430-0929, Japan

  • Kagawa University Hospital_Cardiology

    COMPLETED

    Kita-gun, Kagawa, 761-0793, Japan

  • Keimyung University Dongsan Hospital

    RECRUITING

    Daegu, 42601, South Korea

  • Kings College Hospital

    RECRUITING

    London, SE5 9RS, United Kingdom

  • Kobe City Medical Center General Hospital_Cardiology

    RECRUITING

    Kobe-shi, Hyogo, 650-0047, Japan

  • Korea University Anam Hospital

    RECRUITING

    Seoul, 02841, South Korea

  • Korea University Guro Hospital

    RECRUITING

    Seoul, 08308, South Korea

  • Korea University Guro Hospital

    NOT_YET_RECRUITING

    Seoul, 08308, South Korea

  • Krakowski Szpital Specjalistyczny im. Jana Pawla II

    RECRUITING

    Krakow, 31-202, Poland

  • Lisie Hospital

    RECRUITING

    Kochi, Kerala, 682018, India

  • Medical Research Institute KITANO HOSPITAL_Cardiovascular Medicine

    RECRUITING

    Osaka-shi, Osaka, 530-8480, Japan

  • Medizinische Hochschule Hannover - Kardiologie und Angiologie

    RECRUITING

    Hanover, 30625, Germany

  • NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine

    RECRUITING

    Bunkyo-ku, Tokyo, 113-8603, Japan

  • Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy

    NOT_YET_RECRUITING

    Warsaw, 04-628, Poland

  • National Hospital Organization Mito Medical Center_Cardiovascular medicine

    RECRUITING

    Ibaraki, 311-3193, Japan

  • National Hospital Organization Yokohama Medical Center_Cardiology

    RECRUITING

    Yokohama-shi, Kanagawa, 245-8575, Japan

  • Nemocnice České Budějovice a.s.

    RECRUITING

    České Budějovice, 370 01, Czechia

  • Osaka Metropolitan University Hospital_Cardiovascular Medicine

    RECRUITING

    Osaka-Shi, Osaka, 545-8586, Japan

  • Pratia Prague, s.r.o

    NOT_YET_RECRUITING

    Prague, 130 00, Czechia

  • Radboudumc

    RECRUITING

    Nijmegen, 6525 GA, Netherlands

  • Rhythm Heart Institute

    RECRUITING

    Vadodara, Gujarat, 390022, India

  • Royal Adelaide Hospital - Cardiology Department

    RECRUITING

    Adelaide, South Australia, 5000, Australia

  • Royal Hobart Hospital

    RECRUITING

    Hobart, Tasmania, 7000, Australia

  • Sana Kliniken Berlin-Brandenburg GmbH - Lichtenberg

    COMPLETED

    Berlin, 10365, Germany

  • Sapporo Medical University Hospital_Cardiovascular, Kidney, Metabolism Endocrinology

    RECRUITING

    Sapporo-shi, Hokkaido, 060-8543, Japan

  • Seoul National University Bundang Hospital

    COMPLETED

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seth GS Medical College & KEM Hospital

    RECRUITING

    Mumbai, Maharashtra, 400012, India

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • Shri Mahant Indiresh Hospital

    RECRUITING

    Dehradun, Uttarakhand, 248001, India

  • Sir Ganga Ram Hospital-Cardiology

    RECRUITING

    New Delhi, 110060, India

  • Sir Ganga Ram Hospital-Cardiology

    NOT_YET_RECRUITING

    New Delhi, 110060, India

  • Southampton General Hospital

    RECRUITING

    Southampton, SO16 6YD, United Kingdom

  • St Bartholomew's Hospital - Cardiac Research Office

    NOT_YET_RECRUITING

    London, EC1A 7BE, United Kingdom

  • St Bartholomew's Hospital - Cardiology

    NOT_YET_RECRUITING

    London, EC1A 7BE, United Kingdom

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    RECRUITING

    Krakow, 31-826, Poland

  • The James Cook University Hospital - Cardiology

    RECRUITING

    Middlesbrough, TS4 3BW, United Kingdom

  • The Prince Charles Hospital

    NOT_YET_RECRUITING

    Brisbane, Queensland, 4032, Australia

  • The Royal Brompton Hospital - Respiratory CRF

    NOT_YET_RECRUITING

    London, SW3 6HP, United Kingdom

  • The University of Osaka Hospital_Cardiovascular medicine

    RECRUITING

    Osaka, 565-0871, Japan

  • Trialmed - Midlands

    RECRUITING

    Birmingham, B15 2SQ, United Kingdom

  • Uniklinik Schleswig-Holstein - Med. Klinik III Kardiologie und Internist. Intensivmedizin

    RECRUITING

    Kiel, 24105, Germany

  • Uniklinik TU Dresden - Herzzentrum Dresden GmbH

    RECRUITING

    Dresden, 01307, Germany

  • UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie

    RECRUITING

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Essen - Klinik für Kardiologie und Angiologie

    NOT_YET_RECRUITING

    Essen, 45147, Germany

  • Universitätsklinikum Frankfurt aM - Kardiologie

    RECRUITING

    Frankfurt am Main, 60596, Germany

  • Universitätsklinikum Halle - Innere Medizin III

    RECRUITING

    Halle, 06120, Germany

  • Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu

    RECRUITING

    Wroclaw, 50-556, Poland

  • Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie

    RECRUITING

    Lublin, 20-090, Poland

  • Uniwersytecki Szpital Kliniczny w Bialymstoku

    NOT_YET_RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-276, Poland

  • VMMC & Safdarjung Hospital

    RECRUITING

    New Dehli, New Delhi, 110029, India

  • Victorian Heart Hospital

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • VieCuri - Cardiologie

    RECRUITING

    Venlo, 5912 BL, Netherlands

  • Vseobecna fakultni nemocnice v Praze

    RECRUITING

    Prague, 128 08, Czechia

  • Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu

    RECRUITING

    Przemyśl, 37-700, Poland

  • Wojewodzki Szpital Specjalistyczny W Bialej Podlaskiej

    NOT_YET_RECRUITING

    Biała Podlaska, 21-500, Poland

  • Wonju Severance Christian Hospital

    RECRUITING

    Gangwon-do, 26426, South Korea

  • Wycombe General Hospital

    RECRUITING

    High Wycombe, HP11 2TT, United Kingdom

  • Yokohama City University Medical Center_Cardiovascular Center

    RECRUITING

    Kanagawa, 232-0024, Japan

  • Yokohama City University Medical Center_Cardiovascular Center

    NOT_YET_RECRUITING

    Kanagawa, 232-0024, Japan

  • Zuyderland ziekenhuis - Cardiologie

    RECRUITING

    Heerlen, 6419 PC, Netherlands

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