Engineered immune cells aim to clear leukemia before transplant
NCT ID NCT06197672
First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 24 times
Summary
This early-phase trial tests a new treatment for adults and teens with a hard-to-treat form of acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses specially engineered immune cells (CAR T-cells) that target a protein called CD4 on the leukemia cells. The goal is to safely wipe out remaining leukemia so patients can then receive a stem cell transplant, which offers a chance for long-term control. About 30 participants will receive the cells in increasing doses to find the safest and most effective dose.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITINGIndianapolis, Indiana, 46202, United States
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Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of Miami Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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