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Could a nurse-led online therapy beat severe fatigue in advanced cancer?

NCT ID NCT06511518

Symptom relief Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether an online, nurse-guided version of cognitive behavioral therapy (CBT) can reduce severe fatigue in people with advanced cancer who are receiving palliative systemic treatment. Participants complete a 12-week online CBT program with support from their nurse, after an initial session with a psychologist. Researchers compare the results to earlier studies where psychologists delivered the therapy face-to-face, aiming to see if the simpler approach works just as well.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive behavioral therapy (CBT)
What this could lead to
If successful, this could make effective fatigue relief more accessible for people with advanced cancer by shifting therapy from psychologists to nurses and online delivery.
What could go wrong
The study is small (56 participants) and compares results to past trials rather than a direct control group, so benefits may not hold up in larger, real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Solid (non-brain) tumor patients Inclusion Criteria: * Receive systemic treatment with palliative intent for a solid (non-brain) tumor * Are ≥18 years old * Are proficient in Dutch * Report severe fatigue (Checklist Individual Strength, fatigue severity subscale \[CIS-fatigue\] score ≥35) * A life expectancy of ≥6 months according to their oncologist * Access to a device with internet Exclusion Criteria: * Symptomatic brain metastases * Dual immunotherapy * Have a poor performance status (Karnofsky \<70) * Are currently receiving treatment for a mental disorder. * Treatable somatic cause that could explain the presence of severe fatigue (other than the underlying disease and the cancer treatment itself) * Severe cognitive deficits Glioma patients Inclusion Criteria: * Histologically confirmed diffuse glioma WHO grade 2, 3, or 4 * No oncological treatment for at least two months prior to inclusion * Are ≥18 years old * Are proficient in Dutch * Report severe fatigue (Checklist Individual Strength, fatigue severity subscale \[CIS-fatigue\] score ≥35) * A life expectancy of ≥3 months according to their oncologist * Access to a device with internet Exclusion Criteria: * Signs of radiological or clinical tumor progression at the time of inclusion * Corticosteroid use * Have a poor performance status (Karnofsky \<70) * Are currently receiving treatment for a mental disorder * Treatable somatic cause that could explain the presence of severe fatigue (other than the underlying disease and the cancer treatment itself). * Severe cognitive deficits

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Conditions

The condition(s) this trial relates to.

cancer glioma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer Palliative treatment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical Psychology

    RECRUITING

    Amsterdam, North Holland, 1105AZ, Netherlands

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