Can a cannabis compound sharpen or dull the mind? a study puts CBG to the test
NCT ID NCT05324982
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial investigates how a single oral dose of cannabigerol (CBG), a natural compound from the cannabis plant, affects healthy adults. Over five sessions, participants receive either a placebo or one of four doses of CBG, then undergo eight hours of monitoring including blood and urine tests, heart rate and blood pressure checks, and computer-based tasks measuring attention, memory, and reaction speed. The goal is to understand CBG's safety, how the body processes it, and its short-term effects on the mind and body.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- an oral cannabis compound called cannabigerol (CBG)
- What this could lead to
- If successful, this study could provide the first detailed data on how CBG behaves in the human body, potentially guiding future research into its medical uses.
- What could go wrong
- This is a very early, small study in healthy volunteers, so results may not apply to people with medical conditions. The effects of CBG are still largely unknown, and it may cause side effects like other cannabis compounds.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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12 people
The number who actually took part.
- Started
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Aug 2022
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Have provided written informed consent. 2. Be between the ages of 18 and 55. 3. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests. 4. Test negative for recent cannabis use in urine at the screening visit and again upon admission for the experimental sessions. 5. Test negative for other drugs of abuse, including alcohol, at the screening visit and upon arrival for the experimental session. 6. Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission. 7. Have a body mass index (BMI) in the range of 18 to 30 kg/m2. 8. Blood pressure at Screening Visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg. 9. Self-report prior experience using cannabis, but no use of any cannabinoid products in the prior 30 days. 10. Have not donated blood in the prior 30 days. Exclusion Criteria: 1. Non-medical use of psychoactive drugs other than, nicotine, alcohol, or caffeine in the 30-days prior to the Screening Visit. 2. History of or current evidence of significant medical or psychiatric illness judged by the investigator to put the participant at greater risk of experiencing an adverse event due to exposure or completion of other study procedures. 3. Endorse suicidal intent as indexed by endorsement of questions #4 and #5 on the C-SSRS. 4. Use of an over-the-counter, systemic or topical drug(s), herbal supplement(s), or vitamin(s) within 14 days of experimental sessions; which, in the opinion of the investigator or sponsor, will interfere with the study result or the safety of the subject. 5. Use of a prescription medication (with the exception of birth control prescriptions) within 14 days of experimental sessions; which, in the opinion of the investigator or sponsor, will interfere with the study result or the safety of the subject. 6. History of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina). 7. Enrolled in another clinical trial or have received any drug as part of a research study within 30 days prior to dosing. 8. Epilepsy or a history of seizures. 9. Individuals with anemia for whom, in the opinion of the study team, participation would pose increased medical risk. 10. Women of childbearing potential, or men who are sexually active with a woman of childbearing potential, who are unwilling or unable to use an acceptable method of contraception.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Behavioral Pharmacology Research Unit
Baltimore, Maryland, 21224, United States
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