CBD cream or oil: does it reach your bloodstream?
NCT ID NCT07359976
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a natural hemp extract cosmetic product, containing CBD in coconut oil, enters the blood when applied to the skin or taken by mouth. Twenty healthy adults each tried both methods, with a 15-day break in between. Researchers measured CBD, THC, and their breakdown products in blood and checked urine for THC. The goal was simply to understand absorption, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- CBD extract (cannabidiol) in coconut oil
- What this could lead to
- If successful, this study could help consumers understand how much CBD enters the body from creams or oral oils, and whether it might cause a positive THC drug test.
- What could go wrong
- This is a small, early-stage study with only 20 healthy adults, not designed to treat any disease. Results may not apply to people with medical conditions or long-term use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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Jan 2021
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy adult volunteers (males and females, 18 - 50 years old) with a BMI 19-30. Subjects who were able to ingest or apply test products. The participants understood the requirements of the study. Exclusion Criteria: 1. Individuals less than 18 years of age or over 50 years of age at enrollment; 2. Individuals previously participated in a research study involving administration of the investigational compound within one month prior to the current study; 3. Individuals who were using any recreational drug, specifically marijuana, in the past six months; 4. Individuals with a history of alcoholism; 5. Individuals who have conditions that might have possible interference with the study product absorption, distribution, metabolism, or excretion: previous surgery of the gastrointestinal tract, including removal of parts of the stomach, bowel, liver, gall bladder, pancreas or adjustable gastric band surgery, impaired glucose tolerance, diabetes mellitus, renal disease, edema, hepatic disorder. 6. Individuals who are pregnant or may become pregnant during studies 7. Individuals who are reporting any chronic diseases, such as mental disorders 8. The University of Utah faculty, students, and employees whom the investigators of this study directly supervise
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Division Clinical Pharmacology, SOM, University of Utah
Salt Lake City, Utah, 84108, United States