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CBD drops for anxiety: small study shows promise?

NCT ID NCT02548559

Symptom relief Sponsor: Staci Gruber, Ph.D. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a cannabidiol (CBD) solution placed under the tongue could help adults with moderate to severe anxiety. 46 participants took either full-spectrum CBD, single-compound CBD, or a placebo three times daily for four weeks, alongside their usual treatments. Researchers tracked anxiety levels, mood, sleep, and quality of life to see if CBD offered extra relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cannabidiol (CBD)
What this could lead to
If it works, this could point toward a natural option for easing anxiety symptoms.
What could go wrong
This is a small, early-phase trial with only 46 participants. Results may not apply to everyone, and CBD can cause side effects like drowsiness or digestive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

46 people

The number who actually took part.

Started

Aug 2018

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 or older * Native English speaker or acquired English prior to age 5 * Provides informed consent * Endorses moderate or severe anxiety at the screening visit Exclusion Criteria: * Non-native English speakers * Estimated IQ \< 75 * Pregnancy * Presence of serious medical illness, including liver or kidney disease, neurological disorder, or certain psychiatric disorders * History of head injury or loss of consciousness \>5 minutes * Current use of cannabis or cannabinoid products \>1x/month

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety

Contacts and locations

Locations

  • McLean Hospital Brain Imaging Center

    Belmont, Massachusetts, 02478-9106, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.